Structure 518 o carboxyglutamic acid ill 151

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structure, 518 O'-Carboxyglutamic acid Ill, 151 Carboxylic ester hydrolysis, 86 Carboxypeptidase, 39, 508 Carboxypeptidase 44, C-4 active site, 80-82, C-5 anion binding, 82 intermediates, 82 kinetics, 82 metal 81 proposed catalytic mechanism, 83, 84 structure, 80 Carcinogenic metals, 513 f3-Carotene, 263 Carotenoids, 328 Carp 111 Catalase, 191, 263, 295, 297 mec:hanism, 297 structure, 295 Catechol dioxygenases, 260, 276
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596 INDEX Catechol dioxygenases (continued) active site, 277, 279 iron coordination, 280 mechanism, 280, 282, 283 spectroscopy, 277, 278, 280 structure, 279 substrate activation, 282 Cellular conditions, 253 Ceruloplasmin, 4, 263, 264, 509 Cervical cancer, 527 Charge separation, 329 Chelation therapy, 509, 5 513 Chiton, 30 Chlorocruorin, 169, 170, 184, 185 Chloroheme, 185 structure, 169 Chlorophyll a, 328 Chlorophyll b, 328 Chromate carcinogenicity, I I, 513 Chromatium 385, 386 Chromium, 10 biological significance,S toxicity, 11 Chrysotherapy, 518 Chymotrypsin, Ill, 137, 152 Chymotrypsinogen, 111, 137, 152 Cisplatin (also see cis-DDP), 505, 519 administering with sulfur compounds, 528 clinical activity, 523 clinical picture, 527 discovery, 522 efficacy improvement, 577-579 mechanism of 526 pharmacology, 528 pre-clinical and clinical 524 target, 533 toxicology, 527 Citrate, 111, 393, 422 Clostridium pasteurianum hydrogenase I, 407 Clostridium pasteurianum hydrogenase 407 Co(DIPh H (shape-selective cleavage of nucleic acids), 486 Co(phenh H , 468 Cobalamin (also see coenzyme B 98 Cobalamin reactivity, 100 Cobalt biological significance, 4 chemistry, 205 oxyhemoglobin, 235 porphyrins, 198, 206, 224, 240 toxicity, 510 Cobalt(U)-rubredoxin, 377 Cobalt(H)-substituted carbonic anhydrase, 54,55,59,68 acid-base equilibria, 56, 57 inhibitors, 57, 58, 65-67 isozymes, 56 59,60 NMR, 62, 64, 65 NMRD, 63, 64 Cobalt(II)-substituted copper-zinc super- oxide dismutase, 303 Cobalt(II)-substituted liver alcohol dehy- drogenase, 93 Cobalt(Il)-substituted zinc proteins, 45 Cobalt-dioxygen model systems, 205 Cobalt-oxo 198 Cobalt-porphyrin hemoglobin and myo- globin derivatives, 205 Cobalt-porphyrin oxo species, 205 Cobamides, 98 Coelenterazine, 113 Coenzyme B 12 , 100 biological reactivity and mechanism, 100 Co-C bond, 100 cyano complex (vitamin Bd, 98 enzymes dependent on, 98 physical properties, 98 UIH'UIH,,,, 100 radical formation, 101 spectroscopy, 99 structure, 98, 99 Coenzyme Q, 316 Collagenase, 39 Combination chemotherapy, 527 Complex I (NADH-Q reductase), 325 Complex II (succinate-Q reductase), 325 Complex III (ubiquinol-cytochrome c re- ductase), 326 Complex IV (cytochrome c oxidase), 326 Cooperative ligand binding, 174-182 Copper biological significance, 3 chemistry, 204
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deficiency, 508 model complexes, 270 storage, 16 toxicity, 509 Copper(II) tet b, 300 Copper(II)-substituted carbonic anhy- drase, 69 anion binding, 69 69 70,71 NMRD,71 Copper(II)-substituted liver alcohol dehy- drogenase, 93 Copper(II)-substituted zinc proteins, 46 Copper-containing dioxygen carriers, 185 Copper-dioxygen model systems, 204 Copper-thiolate model complexes, 273 Copper-zinc superoxide dismutase, 298 active site, 301 active-site channel, 302, 304 activity, 299, 300 cobalt derivative, 303 308-310 mhllblt101n, 304 loss of bridging ligand, 304 mechanism, 303 metal-substituted derivatives, 305, 306, 308, 310 reaction with anions, 304 role of copper, 302 role of zinc, 48, 302 spectroscopy, 305, 306-310 structure, 300, 301-303 Core extrusion cluster 391 Correlation time, 63 Corrin, 98
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