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21 Lung Ventilation and Gas Exchange IV

100 120 140 160 180 sea level summit reduced activity

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m ) 0 20 40 60 80
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High Respiratory Frequency is Necessary for Survival on Mt. Everest Oxygen Consumption (liters/min) 0 1 2 3 4 5 R e s p i r a t o y F q u n c ( b h / m ) 10 20 30 40 50 60 70 80 "summit" sea level
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At Extremely High Altitude Diffusional Transport can be Incomplete Due to the Small Concentration Gradient (PAO2-PaO2 ) (From: Clin. Chest Med. 26: 405-414, 2005)
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(From: New England J. Med. 360:140-149, 2009)
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Barometric Pressure and Inspired PO2 at Various Altitudes (From: New England J. Med. 360:140-149, 2009)
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Changes in Arterial PO2, SO2, [Hb], and [O2] on Mount Everest (From: New England J Med 360:140- 149, 2009)
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1. Oxygen diffusion in lung (Low Inspired PO2) 2. Pulmonary hypertension (Generalized Hypoxic Pulmonary Vasoconstriction) 3. Pulmonary edema (Non-Uniformity in Pulmonary Vasoconstriction) 4. Sleep deprivation 5. Weight loss (Hypoxia-Induce GI Hormone Production) Major Health Problems at High Altitude
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Simulated High Altitude/Hpoxia is Used for Training (From Med. Sci. Sports Exer. 39: 1610-1624, 2007) LH – Live High; LL – Live Low TH – Train High; TL – Train Low
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