PracticeExam01Steven-REVISED

Possibilities such as gene alterations andor

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reactivation of previously inactivated genes. Possibilities such as gene alterations and/or mutations are so rare, that we must discount them as possibilities for cancer progression. D: All of the above are false statements. Q4: Of the following, what best describes the correlation between carcinogens and the Ames test? A. Carcinogens, first discovered by Yamagiwa in 1915, are the incomplete combustion of organic compounds. Many of these compounds are hydrocarbons (like coal tar) and if one were to limit their exposure to these substances (e.g. coal tar and tobacco smoke) then their incidence to cancer would decrease by about 36%. B. The Ames test was developed by Bruce Ames to test the potency of potential carcinogens by subjecting bacteria to various compounds such as drugs and biocides. The potency of these
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potential carcinogens were quantified by counting the number of colonies that grew after being subjected, meaning these bacteria developed a mutation that allowed them to grow in the presence of this material. The bacteria subjected to these tests cannot make the amino acid histidine and thus if a mutation has developed, then most likely, the bacteria is making histidine. C. Most cancers, about ~75% in the United States, arise from lifestyle choices. D. All of the above. Answers : A1: A [Chapter 2 – Slide 37] A2: A [Chapter 2 – Slide 38 & 39] A3: D [Chapter 2 – Slide 9 to 12 & 22] A4: D [Chapter 2 – Slide 46 to 56]
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