11.1 Information on toxicological effects Acute oral toxicity LD50 Rat: 19.400 - 36.000 mg/kg (Lit.) Acute inhalation toxicity This information is not available. Acute dermal toxicity LD50 Rabbit: 20.800 mg/kg (Lit.) Skin irritation Rabbit Result: slight irritation (IUCLID) Eye irritation Rabbit Result: slight irritation (IUCLID) Sensitisation Human experience Result: negative (IUCLID) Germ cell mutagenicity Genotoxicity in vitro Ames test Result: negative (IUCLID) Carcinogenicity Did not show carcinogenic effects in animal experiments. (IUCLID) Reproductive toxicity No impairment of reproductive performance in animal experiments. (Lit.) Teratogenicity Did not show teratogenic effects in animal experiments. (Lit.) Specific target organ toxicity - single exposure This information is not available. Specific target organ toxicity - repeated exposure This information is not available. Aspiration hazard This information is not available. 11.2 Further information Hazardous properties cannot be excluded but are unlikely when the product is handled appropriately. Handle in accordance with good industrial hygiene and safety practice.
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006 Catalogue No. 107478 Product name 1,2-Propanediol EMPROVE® ESSENTIAL Ph Eur,BP,USP The life science business of Merck operates as MilliporeSigma in the US and Canada Page 7 of 9 SECTION 12. Ecological information 12.1 Toxicity Toxicity to fish LC50 Oncorhynchus mykiss (rainbow trout): 51.600 mg/l; 96 h OECD Test Guideline 203 Toxicity to daphnia and other aquatic invertebrates EC50 Daphnia magna (Water flea): 34.400 mg/l; 48 h (Lit.) Toxicity to algae IC50 Pseudokirchneriella subcapitata (green algae): 19.000 mg/l; 96 h OECD Test Guideline 201 Toxicity to bacteria EC50 Photobacterium phosphoreum: 26.800 mg/l; 30 min (Lit.) EC50 activated sludge: > 1.000 mg/l; 3 h (Lit.) 12.2 Persistence and degradability Biodegradability 86 %; 20 d OECD Test Guideline 301D 87 - 92 %; 28 d OECD Test Guideline 301C Readily biodegradable 12.3 Bioaccumulative potential Partition coefficient: n-octanol/water log Pow: -0,92 (experimental) (Lit.) Bioaccumulation is not expected. 12.4 Mobility in soil No information available. 12.5 Results of PBT and vPvB assessment PBT/vPvB assessment not available as chemical safety assessment not required/not conducted. 12.6 Other adverse effects Stability in water 2,3 yr reaction with hydroxyl radicals (IUCLID) Additional ecological information Biological effects: When discharged properly, no impairments in the function of adapted biological wastewater treatment plants are to be expected. No ecological problems are to be expected when the product is handled and used with due care and attention.
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006 Catalogue No. 107478 Product name 1,2-Propanediol EMPROVE® ESSENTIAL Ph Eur,BP,USP The life science business of Merck operates as MilliporeSigma in the US and Canada Page 8 of 9 SECTION 13. Disposal considerations Waste treatment methods See for processes regarding the return of chemicals and containers, or contact us there if you have further questions.
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