In a recent systematic review on the effects of

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In a recent systematic review on the effects of hyaluronan in periodontal therapy, the authors concluded that HA has definite positive effect on the probing depth reduction as compared to SRP alone. [16] Apart from the already established role of HA on wound healing, this reduction in the probing depth could also be accredited to the fact that hyaluronan has been shown to directly interfere with inflammation. HA gel has bacteriostatic Table 5: Inter-group comparison of probing pocket depth using Student’s t -test Group ( n =30) PPD in mm (mean±SD) Group A (SRP only) Group B (SRP + HA gel) P Baseline 5.37±0.56 5.37±0.56 0.075 1 month 3.90±0.80* 3.30±0.91* 0.789 3 months 3.33±0.92* 2.37±0.61* 0.760 *Values significant ( P ≤0.05) using Student’s t -test. PPD – Probing pocket depth; SD – Standard deviation; SRP – Scaling and root planing; HA – Hyaluronic acid Table 6: Intra-group comparison of probing pocket depth using repeated measures of analysis of variance Group ( n =30) PPD in mm (mean±SD) Baseline 1 month 3 months P Group A (SRP only) 5.37±0.56 3.90±0.80* 3.67±0.75* 0.000 Group B (SRP + HA gel) 5.37±0.56 3.30±0.91* 2.23±0.67* 0.000 *Values highly significant ( P <0.001) as compared to the baseline levels using multiple comparison test. PPD – Probing pocket depth; SD – Standard deviation; SRP – Scaling and root planing; HA – Hyaluronic acid Table 7: Inter-group comparison of relative attachment level using Student’s t -test Group ( n =30) RAL in mm (mean±SD) Group A (SRP only) Group B (SRP + HA gel) P Baseline 9.10±2.50 9.17±2.04 0.070 1 month 8.07±2.48* 7.50±1.66* 0.023 3 months 7.50±2.58* 6.70±1.64* 0.000 *Values significant ( P ≤0.05) using Student’s t -test. RAL – Relative attachment level; SD – Standard deviation; SRP – Scaling and root planing; HA – Hyaluronic acid Table 8: Intra-group comparison of relative attachment level using repeated measures of analysis of variance Group ( n =30) RAL in mm (mean±SD) Baseline 1 month 3 months P Group A (SRP only) 9.10±2.50 8.07±2.48* 7.50±2.58* 0.030 Group B (SRP + HA gel) 9.17±2.04 7.50±1.66* 6.70±1.64* 0.050 *Values significant ( P ≤0.05) as compared to the baseline levels using multiple comparison test. RAL – Relative attachment level; SD – Standard deviation; SRP – Scaling and root planing; HA – Hyaluronic acid [Downloaded free from on Friday, September 15, 2017, IP: 36.79.172.174]
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Shah, et al .: Hyaluronan as local drug delivery Journal of Indian Society of Periodontology 7 effect on periodontal pathogens. [25,27,36] These properties might reduce bacterial load in the initial stage of healing and hence may have resulted in better improvement in test group patients than control group. HA has been said to have regenerative and osteoinductive potential. [37] In the present study, both the groups showed a statistically significant gain in the attachment at 4 weeks and 12 weeks. However, the test group showed a statistically significant improvement in RAL as compared to the control group. All the properties discussed so far attributed to hyaluronan could ensue these positive effects on the attachment level.
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  • Fall '19
  • Statistical significance, SRP, Periodontitis, Hyaluronan

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