conventional biochemical extraction methods Adelman was able to isolate only

Conventional biochemical extraction methods adelman

This preview shows page 13 - 16 out of 47 pages.

conventional biochemical extraction methods, Adelman was able to isolate onlyDNA   nanostructures   encoding   Hamiltonian   paths,   and   by   determining   theirsequence,   the   explicit   Hamiltonian   path.   It   should   be   mentioned   that   thislandmark   experiment   was   designed   and   experimentally   demonstrated   byAdleman alone, a computer scientist with limited training in biochemistry.3.2 The Non-Scalability of Adelman’s ExperimentWhile this experiment founded the field of DNA computing, it was not scalable inpractice,   since   the   number   of   different   DNA   strands   needed   increasedexponentially with the number of nodes of the graph. Although there can be an13
Background image
enormous number of DNA strands in a test tube (1015  or more, depending onsolution concentration), the size of the largest graph that could be solved by hismethod was limited to at most a few dozen nodes. This is not surprising, sincefinding the Hamiltonian path is an NP complete problem, whose solution is likelyto be intractable using conventional computers. Even though DNA computersoperate   at   the   molecular-scale,   they   are   still   equivalent   to   conventionalcomputers (e.g., deterministic Turing machines) in computational power. Thisexperiment taught a healthy lesson to the DNA computing community (which isnow well-recognized): to carefully examine scalability issues and to judge anyproposed experimental methodology by its scalability.3.3 Autonomous Biomolecular ComputationShortly following Adleman‘s experiment, there was a burst of further experimentsin DNA computing, many of which were quite ingenious. However, almost noneof these DNA computing methods were autonomous, and instead required manytedious   laboratory   steps  to   execute.  In   retrospect,   one   of  the   most  notableaspects   of  Adleman’s   experiment   was   that   the   self-assembly   phase   of   theexperiment was completely autonomous - it required no exterior mediation (thebulk of the labor was in the non-autonomous molecular sorting steps). Thestrategy can be termed generate-and-sort, since all possible answers are createdand   incorrect   solutions   are   subsequently   discarded.   Maximizing   molecular14
Background image
autonomy makes an experimental laboratory demonstration much more feasibleas the scale increases. The remaining article mostly discusses autonomousdevices for bio-molecular computation based on self-assembly.
Background image
Image of page 16

You've reached the end of your free preview.

Want to read all 47 pages?

  • Spring '14
  • DNA, Molecule, DNA nanostructures

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern

Stuck? We have tutors online 24/7 who can help you get unstuck.
A+ icon
Ask Expert Tutors You can ask You can ask You can ask (will expire )
Answers in as fast as 15 minutes