and 70% excreted unchanged in the urine (Woo & Robinson, 2016).
Due to the hepatic metabolism, this medication is contraindicated in patients with history of hepatic dysfunction or jaundice. This medication is also contraindicated in patients with history of hypersensitivity reactions to amoxicillin, clavulanate or to other beta lactam antibacterial drugs including penicillin or cephalosporins (amoxicillin/clavulanate (Rx), 2019). There is currently no black box warning for this medication. Would this treatment vary if Mr. JD was a 10-year-old 78 lb child? Include the class of the medication, mechanism of action, dosing, route, the half-life; how it is metabolized in and eliminated from the body; and contraindications and black box warnings Amoxicillin is the first-line therapy for children with sinusitis with a standard oral dosing of 80-90 mg/kg/d divided into three doses daily for a patient weighing less that 40kg for 10-14 days; patients weighs 35.4kg (Woo & Robinson, 2016, p. 1257). Amoxicillin is in the aminopenicillin family and is metabolized 30% in the liver and excreted 70% unchanged in the urine with a half life of 1 to 1.5 hours (p. 696). The amoxicillin binds to the penicillin- binding proteins, inhibiting bacterial wall synthesis of peptidoglycan. Contraindications include allergy to beta-lactams or penicillin, patients with mono, clostridium difficile or patients with renal or liver disfunction (amoxicillin/clavulanate (Rx), 2019). There are no
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- Spring '19
- Sonya B.
- Beta-lactamase, amoxicillin, Sinusitis, Beta-lactam antibiotic, Clavulanic acid