3 Peroxides Hydrogen peroxide H2 O 2 Strong oxidizing agent but also breaks

3 peroxides hydrogen peroxide h2 o 2 strong oxidizing

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3 . Peroxides Hydrogen peroxide (H 2 O 2 ) - Strong oxidizing agent, but also breaks down rapidly into H 2 O + O 2 oxygen kills anaerobic bacteria - Useful as wound antiseptic, bedsore care, etc. - Commercial / home disinfecting applications (eg. contact lens cleaning solutions) “Accelerated Hydrogen Peroxide” (PerCept ) - H 2 O 2 + proprietary additives (surfactants, etc) which give better stability, greater effectiveness ( better as a surface sanitizer) - Used in hospitals (inc’l RUH) to clean patient care areas
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VIRUCIDAL: 1 Min. at 20° C Proven effectiveness against the Polio Virus (Sabin strain type 1) and allows for a General Virucide claim against enveloped and non-enveloped viruses, including human immunodeficiency virus. BACTERICIDAL: 1 Min. at 20° C Pseudomonas aeruginosa Staphylococcus aureus Salmonella choleraesuis TUBERCULOCIDAL: 5 Min. at 20° C Mycobacterium terrae FUNGICIDAL: 10 Min. at 20° C Trychophyton mentagrophytes BROAD-SPECTRUM SANITIZING: 30 Sec. at 20° C Pseudomonas aeruginosa Staphylococcus aureus Salmonella choleraesuis Staphylococcus aureus (MRSA) Enterococcus faecali, vancomycin resistant Acinetobacter baumanii PerCept Product Claims “Cidal” = Kills “Sanitizing” = Greatly reduces the number of microbes (but may not get rid of them all)
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4 . Heavy metals Bind strongly to cellular proteins Inactivates cellular enzymes and inhibits membrane functions Antiseptic and other uses when used at low concentrations eg. Selenium anti-fungal activity (topical creams) Silver sulfadiazine (burn wound ointment) Zinc compounds (mouthwashes, etc.) Thimerosal (mercury derivative) Copper
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Microbial control on “touch surfaces”
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- Compressed sodium chloride (Outbreaker.ca) Aside: Other ways for the passive control of microbes on surfaces
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- Micropatterned surfaces (Sharklet.com) Aside: Other ways for the passive control of microbes on surfaces Surface Micropattern Resists Bacterial Contamination Transferred by Healthcare Practitioners Mann, et al 2014. Journal of Microbiology & Experimentation
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5 . Halogens (→ protein denaturation) Chlorine Household bleach (Javex) = 5% (50,000 ppm) sodium hypochlorite 1000 - 5000 ppm kills most microbes (& spores) 0.5 - 1.0 ppm to treat drinking water (kills bacteria, but not spores or parasite cysts - eg. Giardia ) Inactivated by organic matter; Poor long-term stability Iodine Less toxic & more stable than chlorine useful as antiseptic “Tincture” (2% Iodine + 70% alcohol ) combined effect “Iodophore” (Iodine + a hydrocarbon carrier ) carrier slows & prolongs the release of iodine eg. Betadine™ (Iodine + polyvinylpyrrolidone) skin antiseptic
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6 . Chlorhexidine Disrupts membranes & denatures proteins One of three antiseptics on the “WHO Essential Medicines List” () Low toxicity, non-irritable, sticks to skin & mucous membranes Coating on catheters & implanted medical devices, etc.
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  • Summer '20
  • Chris Somers
  • Antiseptic

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