Gi ulcers chronic inflammation often helicobacter

This preview shows page 21 - 28 out of 59 pages.

GI ulcers chronic inflammation often Helicobacter pylori infections positive correlations with high-salt diet negative correlations with fruit & vegetable intake
Image of page 21

Subscribe to view the full document.

Acetylsalicylic acid aspirin inhibits COX1 How would aspirin (or ibuprofen) affect ulcers? “666 cases of PUB [peptic ulcer bleeding] and 666 controls; 74.3% cases and 54.8% controls (RR: 2.6; 95% confidence interval (CI): 2.0-3.3) tested positive for H. pylori infection; 34.5% of cases had current NSAID use compared with 13.4% of controls (RR: 4.0; 95% CI: 3.0- 5.4). Respective proportions for low- dose ASA [aspirin] use were 15.8 and 12%, respectively (RR: 1.9; 95% CI: 1.3-2.7). The RR of PUB for concomitant NSAID use and H. pylori infection suggested an additive effect (RR: 8.0; 95% CI: 5.0-12.8), “Gastrointestinal ulcers, role of aspirin, and clinical outcomes: pathobiology, diagnosis, and treatment” “Peptic Ulcer Bleeding Risk. The Role of Helicobacter Pylori Infection in NSAID/Low-Dose Aspirin Users”
Image of page 22
Glycyrrhiza glabra licorice licorice product from roots terpene glycoside (glycyrrhizin) causes sweet flavor many flavonoid and flavonoid-like compounds e.g. licochalcone A appears to be protective against ulcers Special Licorice Extracts Containing Lowered Glycyrrhizin and Enhanced Licochalcone A Prevented Helicobacter pylori-Initiated, Salt Diet-Promoted Gastric Tumorigenesis; The therapeutic effect of FM100, a fraction of licorice root, on acetic acid ulcer in rats FM 100: licorice extract Ulcer index: sum of area of ulcers
Image of page 23

Subscribe to view the full document.

Phenylpropanoids & ulcers Antioxidants seem protective against ulcers Capsicum annuum (pepper) capsaicin (hot & antioxidant) low dose: protective? high dose: exacerbating? Camellia sinensis (tea) catechins (flavonoids) Healing mechanisms of the hydroalcoholic extract and ethyl acetate fraction of green tea ( Camellia sinensis (L.) Kuntze) on chronic gastric ulcers; Capsaicin protects endothelial cells and macrophage against oxidized low-density lipoprotein-induced injury by direct antioxidant action; Capsaicin consumption, Helicobacter pylori positivity and gastric cancer in Mexico; Chili— Protective factor against peptic ulcer? “The risk of GC was increased (OR = 1.71; 95% CI = 0.76 - 3.88) among high-level consumers of CAP (90-250 mg of capsaicin per day, approximately 9-25 jalapeño peppers per day) as compared to low-level consumers (0-29.9 mg of capsaicin per day, approximately 0 to less than 3 jalapeño peppers per day; p for trend p = 0.026 )” “The median number of times of chili use per month was eight in the ulcer group (25- 75% quartiles 1-30) compared to 24 (8-56) in the control group (P < 0.001).” Acetic acid induced ulcers in rats; C=control; ome = omeprazole (PPI); GEt = green tea
Image of page 24
Dyspepsia indigestion Gastric emptying peristaltic movement of gastric contents Constipation & Diarrhea
Image of page 25

Subscribe to view the full document.

Aquaporins water channels (AQP3) transport water from lumen of large intestine into cells 1.5—2.0 L of water/day absorbed by colon diarrhea – frequent/watery stools constipation – infrequent/dry stools GI lumen
Image of page 26
Papaver somniferum opium poppy opium (fruit exudate) morphine, codeine
Image of page 27

Subscribe to view the full document.

Image of page 28

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern