1 ALL by contrast is a disease of lymphoid progenitors immature lymphocytes

1 all by contrast is a disease of lymphoid

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marrow and subsequently within the peripheral blood (Figure 6.1). ALL, by contrast, is a disease of lymphoid progenitors (immature lymphocytes), resulting in infiltration and proliferation of the bone marrow by lymphoid blasts (Figure 6.2). Historically, the French–American–British classification was used
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to subdivide AML and ALL on the basis of morphological criteria. This was superseded by the World Health Organization classification, which incorporated morphological findings, as well as immunophenotypic and genetic/molecular abnormalities. The WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues was updated in 2008 to include established subtypes of AML and ALL with recurrent genetic abnormalities. Epidemiology ALL is the most common cancer of childhood. The highest incidence is seen in children 0–4 years of age (5.2 cases per 100 000 per year), falling to 1.9 cases per 100 000 per year in children 10–14 years of age. It is a much rarer leukaemia in adults, though there is a secondary rise in incidence in patients over the age of 40, but not to the levels seen in childhood. Generally, prognosis in childhood is much more favourable compared with ALL in adults. AML is much rarer in childhood and much more common in adults, with an overall incidence of 3.4 per 100 000 per year, and nearly two thirds of cases occurring in patients over the age of 60 years. Generally, prognosis in younger patients (
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  • Spring '18
  • Mr. kanor
  • Leukemia, Bone marrow, Acute myeloid leukemia

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