22 23 proliferation il4 il6 activated 25

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23 Proliferation IL4 IL6 activated
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25 Intracellular vs extracellular antigens APC = macrophages, dendritic cells & B cells
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26 Humoral Immune Response Animation
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29 Humoral mediated immunity (HMI) B cells Plasma cells Memory B cells
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30 B Lymphocyte Electron Micro- scope picture B lymphocyte in whole blood, light microscope
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31 B Lymphocyte Antibody receptor for antigen B Cell Plasma Cell Antibody Antigen + Helper T Cell Antigen Granules full of antibody IL6
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32 Clonal selection of B cells
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34 Activation of B cells 1 2 3 1 1 1
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35 Clonal Selection of B cells Self Ags Non-self Ags IL-4 Bone Marrow Lymph node
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36 Clonal selection theory 1. Each lymphocyte bears a single type of receptor with a unique specificity . 2. Receptor occupation is required for cell activation. 3. The differentiated effector cells derived from an activated lymphocyte will bear receptors of identical specificity as the parental cell. 4. Those lymphocytes bearing receptors for self molecules will be deleted at an early stage.
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37 Overview of Antibody Mediated Immunity Ingested microorganisms Antigen fragment MHC protein Helper T lymphocyte Macrophage Antibody (to bloodstream) Activated Helper T lymphocyte Plasma cells Microbial antigen Antibody receptor B lymphocyte Macrophage Figure 3.9
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