The majority of breast cancers are ESTROGEN DRIVEN. o They are triggered and sustained by the body's production of the female hormone estrogen. o On the surface of cells in our body we have receptor molecules, which tend to be proteins. o In this case, a cell is ready to become a tumor if it is stimulated by estrogen. o Lock and key effect: If the key fits into the lock, in this case the estrogen fits into the receptor, it can trigger activity that is the irregular multiplication of cells. If estrogen can do that, then what about compounds that block those receptors? o ISOFLAVONES are estrogen-like compounds that are found in soybeans. Block the receptors that are triggered by estrogen o It's sort of like having the key, but it's the wrong key. It fits the lock so therefore, it prevents the right key from entering, but it itself does not unlock the lock. LIGNANS: found in FLAXSEEDS o Are estrogen-like compounds found in plants that also have antioxidant properties. More specifically, they have anticancer properties o Dr LILIAN THOMPSON - the University of Toronto Investigates breast cancer Has given breast cancer patients flaxseed, because of the high lignin content, baked into muffins
These muffins contain about 25 grams of ground flaxseed This study showed, for the first time, the potential of dietary modification with flaxseed and its components such as lignans, in reducing tumor growth in patients with breast cancer comparable to the effects seen with preoperative tamoxifen In the case of breast cancer, lignans and isoflavones can play a very interesting role VIDEO 6 PROSTATE CANCER: The most commonly seen cancer in men hormone driven cancer Canadian statistics: o About 20,000 cases of prostate cancer diagnosed every year in Canada and roughly 20% eventually die from the disease Most men who are diagnosed with prostate cancer actually die with the disease, not because of it, because it tends to be a slow-growing cancer TOMATOES: used to avoid prostate cancer? o LYCOPENE: red pigment Found in other fruits and vegetables: pink grape fruit, watermelon o WAYNE STATE LYCOPENE TRIAL: HUMAN INTERVENTION STUDY Taking a group who has some sort of problem and you're trying to remedy that problem with some sort of intervention 15 patients were given 15 milligrams of lycopene twice daily for 3 weeks prior to prostate surgery When compared with patients given a placebo, the tumors were smaller and showed reduced malignancy o HEALTH PROFESSIONALS Follow-up Study 50,000 men Not an intervention study cohort study Compared with men consuming less than 1.5 servings a week of lycopene products, those eating more than 10 servings of tomato had a 35% reduction in prostate cancer risk o He wouldn’t suggest that tomatoes prevent cancer GARLIC: o Studies that have shown that people who consume a lot of garlic do reduce the risk of certain kinds of cancer.
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- Spring '11