Neurological Disease Dementia Copyright 2017 Wolters Kluwer All Rights Reserved

Neurological disease dementia copyright 2017 wolters

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Neurological Disease – Dementia
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Signs and Symptoms of HIV/AIDS (cont.) Signs and Symptoms of HIV/AIDS (cont.) Secondary Infections – Pneumocystis carinii, disseminated herpes simplex
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Drugs Used to Treat HIV/AIDS Drugs Used to Treat HIV/AIDS Reverse Transcriptase Inhibitors Protease Inhibitors Nucleosides- NNRTI and NRTI Fusion Inhibitors CCR5 Coreceptor Antagonist Integrase Inhibitors
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Non nucleoside /Nucleoside Reverse Transcriptase Inhibitors Non nucleoside /Nucleoside Reverse Transcriptase Inhibitors Indications – Bind directly to HIV reverse transcriptase blocking both RNA and DNA dependent DNA polymerase activities /compete with the naturally occurring nucleosides Pharmacokinetics – Rapidly absorbed from the GI tract, except (Didanosine) metabolized in the liver, excreted in the urine and feces Contraindications – Pregnancy and lactation except zidovudine, Lamivudine and zalcitabine should not be given together Adverse Reactions – Headache, nausea, vomiting, rash, chills, diarrhea, flu-like syndrome of fever, muscle aches and pains and bone marrow suppression with Zididovine
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Protease Inhibitors Protease Inhibitors Indications – Block protease activity within the HIV virus Pharmacokinetics – Rapidly absorbed in the GI tract, metabolized in the liver and excreted in urine and feces Contraindications – Pregnancy and lactation and mild to moderate hepatic dysfunction Adverse Reactions- GI effects, changes in liver function, elevated cholesterol and triglyceride levels may occur as well as Stevens-Johnson syndrome risk Drug-to-Drug Interactions- Fosamprenavir, pimozide, rifampin, triazolam, or midazolam
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Interactions Interactions
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Fusion Inhibitors Fusion Inhibitors Indications – Prevents the fusion of the virus with the human cellular membrane Pharmacokinetics – Given sub-q; metabolized in the liver it is recycled in the tissues it is not excreted Contraindications – Use cautiously with lung disease and pregnancy Adverse Reactions – Headache, dizziness, myalgia, nausea, vomiting, and diarrhea Drug-to-Drug Interactions – No reported drug interactions
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Copyright © 2017 Wolters Kluwer • All Rights Reserved CCR5 Coreceptor Antagonist CCR5 Coreceptor Antagonist Indications – Blocks the receptor site on the cell membrane to which the HIV virus needs to interact to enter the cell Pharmacokinetics –Rapidly absorbed from the GI tract, metabolized in the liver, and excreted primarily through the feces Contraindications –Hypersensitivity to any component of the drug, nursing mothers and liver disease Adverse Reactions – Dizziness and changes in consciousness
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  • Spring '14
  • PaulG.Steffes
  • Ode, Antiretroviral drug, Wolters Kluwer Health, Wolters Kluwer, Reverse transcriptase

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