The thyroid stimulating hormone tsh stimulates the

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Page 15 59. The thyroid stimulating hormone (TSH) stimulates the thyroid to secrete thyroid hormone. A patient presents in your office with a benign tumor on his thyroid that is secreting large amounts of thyroid hormone, even without stimulation by TSH. You sequence the gene encoding the TSH receptor from the tumor cells. It is a predicted seven trans-membrane receptor. When the results come back from the DNA sequencing lab, you find point mutations in the third intracellular loop of the TSH receptor. From what you’ve learned in BIS104, what do you hypothesize is the molecular explanation of what is going on?
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