Can be quiescent dormant until needed o often

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Can be quiescent (dormant until needed) o Often proliferate better at low oxygen levels (embryo, wound repair) o High glucose utilization Migratory potential o Often highly mobile o Not destructive or tissue architecture Humoral effects o Some secrete various growth factors o Often have restorative influences on local host microenvironment (neuroprotection) Cell replacement, regeneration of diseased tissues Characteristics of Cancer Stem Cells May consist of a mix of cell types o Cancer stem cells: can be quiescent (dormant) or active o Actively dividing cells o Less malignant cell types Slower or no proliferation Partially differentiated Cancer stem cells would serve as stem cells for the cancer o Renew themselves & the disease o Generate daughter cells Could be (in some cases) less malignant, more differentiated o Metastasize o Debulking a tumor could yielf short term relief from mass effect but no cure o To cure cancer, the cancer stem cells must be eliminated (killed, differentiated or reprogrammed) o If cancer stem cells became quiescent, they could survive chemotherapy If later reactive → “cute” would be over Potentially explains the clinical phenomenon of remission Young vs. Old Stem Cells The “younger” the stem cells, the more it can do The “older” the stem cell, the better it behaves
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