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PHRM 514 Allergic Rhinitis Fall '12 (2)

O perennial vs o episodic o mild vs o moderate severe

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o Perennial vs. o Episodic o Mild vs. o Moderate-Severe and o Intermittent vs. o Persistent Apgar DA. Allergic Rhinitis. In: Chisholm-Burns MA, Schwinghammer TL, Wells BG, et al., editors. Pharmacotherapy: Principles and Practice. 2nd ed. New York: McGraw Hill Medical; 2010:1047-1049.
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Seasonal Allergic Rhinitis o “Hay fever” o Occurs at predictable times of year when specific allergens are present o Usually spring and fall when plants bloom May JR, Smith PH. Allergic rhinitis. In: DiPiro JT, Talbert RL, Yee GC, et al., editors. Pharmacotherapy a pathophysiologic approach. 8th ed. New York: McGraw Hill Medical; 2011:1649-1652.
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Match the pollens with the seasons they would most likely be the cause of allergic rhinitis. 1. Weed-Spring, Tree-Fall, Grass-Summer 2. Weed-Spring, Grass-Fall, Tree-Summer 3. Weed-Summer, Grass-Spring, Tree-Fall 4. Weed-Fall, Grass-Spring, Tree-Summer 5. Weed-Fall, Grass-Summer, Tree-Spring
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Tree pollens Weed pollens Grass pollens May JR, Smith PH. Allergic rhinitis. In: DiPiro JT, Talbert RL, Yee GC, et al., editors. Pharmacotherapy a pathophysiologic approach. 8th ed. New York: McGraw Hill Medical; 2011:1649-1652.
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What are examples of indoor allergens?
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Perennial Allergic Rhinitis o Occurs year round o Indoor allergens n House dust mite fecal proteins n Animal dander n Cockroaches n Mold o Less common o Present year round (growth on decaying vegetation occurs seasonally) May JR, Smith PH. Allergic rhinitis. In: DiPiro JT, Talbert RL, Yee GC, et al., editors. Pharmacotherapy a pathophysiologic approach. 8th ed. New York: McGraw Hill Medical; 2011:1649-1652.
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Review of Nasal Physiology o Prepares incoming gases and their contents for the lungs o Heats, humidifies, and cleans the air o Usual process: n Air passes through the nose n Turbulence throws particulate matter against mucus n Nasal cilia cause the mucus to move posteriorly and it is swallowed n Trapped foreign particles are removed via the GI tract and do not reach the lungs May JR, Smith PH. Allergic rhinitis. In: DiPiro JT, Talbert RL, Yee GC, et al., editors. Pharmacotherapy a pathophysiologic approach. 8th ed. New York: McGraw Hill Medical; 2011:1649-1652.
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Nasal Vascular Tissue o Parasympathetic stimulation n Fibers vasodilate n Erectile tissue size increases n Airways narrow o S y m p a t h e t i c s t i May JR, Smith PH. Allergic rhinitis. In: DiPiro JT, Talbert RL, Yee GC, et al., editors. Pharmacotherapy a pathophysiologic approach. 8th ed. New York: McGraw Hill Medical; 2011:1649-1652.
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Immune Response to Allergens Exposure 1 Exposure 2 and subsequent exposures May JR, Smith PH. Allergic rhinitis. In: DiPiro JT, Talbert RL, Yee GC, et al., editors. Pharmacotherapy a pathophysiologic approach. 8th ed. New York: McGraw Hill Medical; 2011:1649-1652.
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Apgar DA. Allergic Rhinitis. In: Chisholm-Burns MA, Schwinghammer TL, Wells BG, et al., editors. Pharmacotherapy: Principles and Practice. 2nd ed. New York: McGraw Hill Medical; 2010:1047-1049. Rosenwasser L. New insights into the pathophysiology of allergic rhinitis. Allergy Asthma Proc 2007;28:10-15.
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Which of the following is an effect of histamine?
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