BIO314 Full Practice Exam 2

Which of the following statement is not true a

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13) Which of the following statement is NOT true? a) Neurofibromin has a homologous domain to RasGAP, which participates in restoring Ras from the active GTP-bound state to the inactive GDP-bound state. b) Wnt signaling allows inactivation of GSK-3β which in turn degrades β-catenin to send
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pro-survival signals. c) APC is a tumor suppresor gene that downregulates β-catenin. d) Guanine neucloeotide exchange factors (GEFs) allows phosphorylation of GDP-bound proteins to reach GTP-bound state. e) a and b are false. 14) Which of the following statement is NOT true? 15) Based on what we have learned in class so far, transtormed cells acquired some way to proliferate even in the absence of proper signals. These cells seem to have hypomethylated genome which gives easier access to transcribe genes and further protein synthesis. On the other hand, hypermethylated genome should theoretically inhibit tumor growth then. However, Hypermethylation is also dangerous to us. Which of the following explains the best why hypermethylated genome is also harmful? 16) Which of the following statements regarding Beta-catenin signaling is/are false? 17) Without a functioning VHL (Von Hippel-Lindau) gene, HIF-1α can upregulate the
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expression of: a) VEGF b) PDGF c) Erythropoietin d) A & B. e) All of the above.
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