Hematogenouslyto bones and joints to cause infections

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hematogenouslytobones and joints tocause infectionsCulture on chocolateagar or pepticdigestagarDoes not grow onblood-agarRequires heminandNADIntrinsicallysensitiveto all antibiotics usedfor gram negativebacteria80% have ampicillinresistance (TEM-1beta-lacamase)Treat HIB with thirdgenerationcephalosporinHas an invariantpolyribitolphosphate(PRP) capsuleConjugated PRPvaccine preventsdiseaseNon-typeableH-flu (NTHi)Gram negativecoccobacilliOral floraPerson-to-personLocalized, not invasive infectionsOuter membrane proteins on thebacteria protect againstphagocytosisand complementInvade sterile resipratoryepithelia(nasal sinuses, middle ear, bronchi)Avoid immune response by varyingsugars and linkages in LOS andexcluding phospholipids from outermembranePilibind sialicacid residues on cellsand mucinOtitismediaSinusitisChronic bronchitisCulture on chocolateagar or pepticdigestagarRequires heminandNADIntrinsicallysensitiveto all antibiotics usedfor gram negativebacteria80% have ampicillinresistance (TEM-1beta-lacamase)No acquired immunitybecause there is toomuch antigenicvariation (e.g.variation oflipooligosaccharides(LOS) and OMP)a—Fastidious Bacteriaand mucinLOS modified withphosphorylcholineto mimic hostPAF and invade cellsType III/IV secretion systemsdeliver proteins into eukaryoticcells to disrupt host immuneresponses and cause cytoskeletalreorganizationSecretes many things: elastase, AP,LasAprotease, hemolysin,rhamnolipids, pyocyaninBordatellapertussisSmall gramnegative rod,faintly stainingDroplet spread;plentiful insecretions100% attack rateof non-immunefamiliesAdherence: filamentoushemagglutinin, fimbriae, pertactin-OMPDisease is toxin-mediated:PT(inhibits G-protein signaling), cya(anti-inflammatory and anti-phagocytic), tracheal cytotoxin(killsciliated epithelial cells), Lipid A(toxic)Whooping cough(paroxysmal coughingleads to “whooping”sound due to smallairways)URI or pneumonia inadultsGrowth requiresmany nutrients and isslow –not doneroutinelyPCRDFASerologyInfection but notvaccine stimulates IgAantibody productionPT and FIMAntibiotics during thecatarrhal stage canprevent progressionMacrolidesortrimethoprimsulfareduce infectivity butdo not shorten illnessin the whooping stagePrevent with acellularvaccine directedagainstpertussistoxin,filamentoushaemagglutinin,pertactin, and twoserotypes of fimbrialantigens oragglutinogens3 doses of vaccine arerequiredAdults need booster
ToxinMechanismRibosomeInactivate 28s rRNA(by cleaving off an adenosine residue) toEnterobacteriacaeEnteric Bacteria:Gramnegative bacteria associatedwith GI flora or disease.

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Term
Spring
Professor
staff
Tags
Bacteria, Escherichia coli, gram negative bacteria, GI Tract, Gram positive bacteria

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