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PHRM 514 STD's Fall 2012 (1)

Chapter 176 chlamydial infections in longo dl fauci

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Gaydos CA, Quinn TC. Chapter 176. Chlamydial Infections. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson  JL, Loscalzo J, eds.  Harrison's Principles of Internal Medicine . 18th ed. New York: McGraw-Hill; 2011.  http://www.accessmedicine.com.proxy1.lib.tju.edu:2048/content.aspx?aID=9102676. Accessed October 23, 2011.
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Chlamydia:  Clinical  Presentation Males Females Incubation  Period 35 days 7-35 days Symptom Onset 7-21 days 7-21 days Most Common  Site of Infection Urethra Endocervical  canal Other Sites of  Infection Rectum, eye,  oropharynx Urethra, eye,  rectum,  oropharynx Knodel, LC.  Sexually transmitted diseases.  In:  DiPiro JT, Talbert RL, Yee GC, et al., editors.  Pharmacotherapy a  pathophysiologic approach.  8th ed.  New York:  McGraw Hill Medical; 2011:2011-2028.
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Chlamydia:  Clinical  Presentation Males Females Symptoms More than 50% of urethral  and rectal asymptomatic Urethral infection   – mild  dysuria, discharge Pharyngeal infection   –  mild pharyngitis Endocervical infection  –  More than 66%  asymptomatic Urethral infection  –  dysuria and urinary  frequency uncommon Pharyngeal infection  –  same as for males Signs Scant to profuse, mucoid to  purulent urethral or rectal  discharge Rectal  – pain, discharge,  Abnormal vaginal  discharge, uterine  bleeding, scant to profuse  purulent urethral or rectal  Knodel, LC.  Sexually transmitted diseases.  In:  DiPiro JT, Talbert RL, Yee GC, et al., editors.  Pharmacotherapy a  pathophysiologic approach.  8th ed.  New York:  McGraw Hill Medical; 2011:2011-2028.
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Chlamydia:  Complications Males Females Complications n Epididymitis n Reiter  syndrome n Pelvic  inflammatory  disease May lead to  ectopic  pregnancy,  infertility n Reiter  syndrome Knodel, LC.  Sexually transmitted diseases.  In:  DiPiro JT, Talbert RL, Yee GC, et al., editors.  Pharmacotherapy a  pathophysiologic approach.  8th ed.  New York:  McGraw Hill Medical; 2011:2011-2028.
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Chlamydia:  Diagnosis n Detection of  C. trachomatis n NAAT’s, culture, direct immunofluorescence,  enzyme immunosorbent assay (EIA), and  nucleic acid hybridization § Women – endocervix or vaginal swabs; urine § Men – urethral swabs, urine § Rectal  and oropharyngeal swabs § NAAT’s are the most sensitive – can use with  urine – self-collected specimens Knodel, LC.  Sexually transmitted diseases.  In:  DiPiro JT, Talbert RL, Yee GC, et al., editors.  Pharmacotherapy a  pathophysiologic approach.  8th ed.  New York:  McGraw Hill Medical; 2011:2011-2028.
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