Which immunoglobulin Ig is present in childhood asthma a IgM c IgE b IgG d IgA

Which immunoglobulin ig is present in childhood

This preview shows page 243 - 245 out of 289 pages.

11. Which immunoglobulin (Ig) is present in childhood asthma? a. IgM c. IgE b. IgG d. IgA ANS: C Included in the long list of asthma-associated genes are those that code for increased levels of immune and inflammatory mediators (e.g., interleukin [IL]–4, IgE, leukotrienes), nitric oxide, and transmembrane proteins in the endoplasmic reticulum. None of the other options are associated with childhood asthma. PTS: 1 REF: Pages 1308-1309 12. Which T-lymphocyte phenotype is the key determinant of childhood asthma? a. Cluster of differentiation (CD) 4 T-helper Th 1 lymphocytes b. CD4 T-helper Th 2 lymphocytes c. CD8 cytotoxic T lymphocytes d. Memory T lymphocytes ANS: B Asthma develops because the Th 2 response (in which CD4 T-helper cells produce specific cytokines, such as interleukin [IL]–4, IL-5, and IL-13) promotes an atopic and allergic response in the airways. This selection is the only option that accurately identifies the appropriate T-lymphocyte phenotype.
PTS: 1 REF: Page 1309 13. Which cytokines activated in childhood asthma produce an allergic response? a. Interleukin (IL)–1, IL-2, and interferon-alpha (IFN- α ) b. IL-8, IL-12, and tumor necrosis factor-alpha (TNF- α ) c. IL-4, IL-10, and colony-stimulating factor (CSF) d. IL-4, IL-5, and IL-13 ANS: D Related to asthma, IL-4 and IL-13 are particularly important for B-cell switching to favor immunoglobulin E (IgE) production, and IL-5 is crucial for local differentiation and enhanced survival of eosinophils within the airways. This selection is the only option that accurately describes how cytokines produce a childhood asthmatic response. PTS: 1 REF: Page 1309 14. Which statement accurately describes childhood asthma? a. An obstructive airway disease characterized by reversible airflow obstruction, bronchial hyperreactivity, and inflammation b. A pulmonary disease characterized by severe hypoxemia, decreased pulmonary compliance, and diffuse densities on chest x-ray imaging c. A pulmonary disorder involving an abnormal expression of a protein, producing viscous mucus that lines the airways, pancreas, sweat ducts, and vas deferens d. An obstructive airway disease characterized by atelectasis and increased pulmonary resistance as a result of a surfactant deficiency ANS: A Asthma is an obstructive airway disease characterized by reversible airflow obstruction, bronchial hyperreactivity, and inflammation. This selection is the only option that accurately describes childhood asthma. PTS: 1 REF: Page 1308

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture