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Third generation tsh chemiluminometric assays w

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Explain the relationship between TSH and Free T4. Third generation TSH chemiluminometric assays w/ detection limits of 0.01 mU/L are less likely to give false negative results and can more accurately distinguish between euthyroidism and hyperthyroidism while second and third generation TSH assays are used to monitor and adjust thyroid hormone replacement therapy as well as screen for both hyperthyroidism and hypothyroidism. The sensitivity of third generation TSH assays has led to the ability to detect what is termed subclinical disease or a mild degree of thyroid dysfunction. In subclinical hypothyroidism, the TSH is minimally increased while the free T4 stays w/in the normal range. Likewise, in subclinical hyperthyroidism, the TSH is suppressed while the free T4 is normal. 5. Given a set of thyroid laboratory test results, list the suspected thyroid disorder. Interpretation of Thyroid Tests Low Free T4 Normal Free T4 High Free T4 Low TSH Secondary hypothyroidism; Subclinical hyperthyroidism; Hyperthyroidism
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Thyroid Function – Objectives Severe nonthyroidal illness Nonthyroidal illness Normal TSH Secondary hypothyroidism; Severe nonthyroidal illness Normal Artifact; Pituitary hyperthyroidism; laboratory draw within 6 hours of thyroxine dose High TSH Primary hypothyroidism Subclinical hypothyroidism Test artifact; Pituitary
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