Intermediate or ambiguous sexual development 1 in 100 children born with some

Intermediate or ambiguous sexual development 1 in 100

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Intermediate or ambiguous sexual development 1 in 100 children born with some degree of sexual ambiguity 1 in 2000: ambiguity is large enough to make gender assignment difficult Sex is determined by sex chromosomes & circulating androgens during prenatal development Alterations in those -> alterations in sexual development Compare human sexual orientation and gender identity. Sexual orientation: Prenatal Androgens Brain anatomy
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3 rd interstitial nucleus of Cajal Intersex conditions Congenital adrenal hyperplasia Increased androgens during critical period associated with homosexuality in females Androgen insensitivity syndrome Decreased androgenic action during critical period associated with homosexuality in males Maternal stress Stress hormones cross placenta and antagonize effects of testosterone on developing brain Gender Identity Bed nucleus of the stria terminalis (BNST): nucleus embedded in axons connecting amygdala with hypothalamus What happens during puberty? Are the effects organizational, activational, or both? What is the role of sex-limiting genes? For sexual development of body, you should be able to describe thesteps starting with SRY gene being turned on. Understand what happens in females as well. What is the aromatization hypothesis?
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Understand the studies in rats where testosterone levels or estrogenlevels were manipulated at birth and/or in adulthood. When is testosterone acting organizationally and when it is activational?What happens during the critical period of development constitutes the organizational (developmental) effects of hormones. Describe the menstrual cycle.
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  • Fall '08
  • Glendenning
  • Circadian rhythm, SCN,  Androgens

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