Broad Spectrum Penicillins Broad-spectrum penicillins (aminopencillins)oAmpicillinoAmoxicillinAdverse effectsoRash oDiarrhea~Broad spectrum penicillins: we have the amipicillin, amoxicillin. Amoxicillin is given orally and some of the most common adverse effects can be rash, diarrhea, nausea, vomiting. Ampicillin and amoxicillin have the same antimicrobial spectrum as penicillin G their going to increase activity against gram negative bacilli. These are good drugs when a pt reports (usually a kid) have a ear infection due to haemophilus influenza, e. coli, salmonella, shigella. Extended- Spectrum PenicillinsAntipseudomonal penicllins oTicarcillin and piperacillinBroad spectrum, but penicillinase sensitiveEffective against organisms susceptible to the aminopenicillins plus Pseudomonas aeruginosa, Enterobacter species, Proteus (indole positive),Bacteroides fragilis, and many Klebsiella speicies.~Extended spectrum penicillin is prescribed for most likely Pseudomonas, and that’s IMPORTANT TO KNOW about the extended spectrum. Penicillin CombinationsBeta-lactamase inhibitors oClavulanic acid, tazobactam, sulbactamExtends antiomicrobial spectrum when combined with penicillinase- sensitive antibioticsoAmpicillin/ sulbactam[Unasyn]oAmoxicillin/ clavulanic acid [Augmentin]oTicarcillin/ clavulanic acid [Timentin]oPiperacillin/ tazobactam [Zosyn]~We have combinations like the ampicillin with the sulbactam which is uasyn, it is usually its given IV. And the zosyn, that’s usually for pseudomonas also.