A Life Decoded: My Genome: My Life (Penguin, 2007)in which he relatesthe history of the Human Genome Project, discusses the implications of this kind of information, and relates it back to his own life. I highly encourage you to read this book when you have time.There are a series of vignettes in the book in which Craig Venter discusses specific genes that relate to a human disorder or trait. He then examines the specific allele variants that he is carrying (diploid genotype).You will be given one of these vignettes and asked to discuss the following: Gene nameShort description of the condition or disorderCytological locationGene structure (intron/exon structure; alternate splice variants)Gene product (protein, RNA)Gene expression patterns (tissues, developmental timing)Gene product functionConsequences of mutant allelesAllele variants – sequence differences, loss of function/gain of function, etc.Distribution of allelesImplications for diagnosis, prediction, treatment, …The project should be done in groups of three (or two) - ALL members of the group must contribute to the collectionand preparation of the project material. Your project will then be presented in two formats:1) An oral presentation in your tutorial during the three weeks between October 25th and November 12th.
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