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9. How many tritium atoms are incorporated in acetate if a molecule of palmiticacid is oxidized in 100% tritiated water?10. What would be the consequences of a carnitine deficiency for fatty acidoxidation?11. Based on the mechanism for the methylmalonyl-CoA mutase (Figure 23.21),write reasonable mechanisms for the reactions shown below.123
Chapter 23 . Fatty Acid CatabolismH2CHCOHOHCHOHHH3CHCOHCHHOHHCH2HCCOO-NH3+-OOCCHH2CNH3+CHOHHH3CCOHH3CCHHCOHH2CCOHHHCOH-OOCCHHCC H3C OO-NH3++ NH4++ H2O+ H2OEthanolamine AcetaldehydeGlycerol -Hydroxypropionaldehyde1,2-Propandiol propionaldehydepropanedioldehydraseglyceroldehydraseethanolaminedeaminaseGlutamate threo--Methyl-L-aspartateglutamatemutaseIn each reaction the positions of the groups in boxes are exchanged. For the last threereactions, rearrangements of hydroxyl groups or an amino group leads to production ofunstable intermediates. These are shown below.H3CHCHCHOHOHH3CCHHCOHH2CHCOHHCHOHOHH2CCOHHHCOHH2CHCHOHNH3+H3CCOH+ NH4++ H2O+ H2Opropanedioldehydraseglyceroldehydraseethanolaminedeaminase