How many tritium atoms are incorporated in acetate if a molecule of palmitic

How many tritium atoms are incorporated in acetate if

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9. How many tritium atoms are incorporated in acetate if a molecule of palmiticacid is oxidized in 100% tritiated water? 10. What would be the consequences of a carnitine deficiency for fatty acidoxidation? 11. Based on the mechanism for the methylmalonyl-CoA mutase (Figure 23.21),write reasonable mechanisms for the reactions shown below. 123
Chapter 23  Fatty Acid Catabolism H 2 C H C OH OH C H OH H C H H OH H 3 C H C OH - OOC C H H CH 2 HC COO - NH 3 + H 2 C NH 3 + C H OH H H 3 C C O H H 3 C C H H C O H - OOC C H HC CH 3 COO - NH 3 + H 2 C C OH H H C O H + NH 4 + + H 2 O + H 2 O 124
Chapter 23  Fatty Acid Catabolism H 2 C H C OH OH C H OH H H 3 C H C OH C H H OH H CH 2 HC COO- NH 3 + -OOC C H H 2 C NH 3 + C H OH H H 3 C C O H H 3 C C H H C O H H 2 C C OH H H C O H -OOC C H HC C H 3 C OO- NH 3 + + NH 4 + + H 2 O + H 2 O Ethanolamine Acetaldehyde Glycerol -Hydroxypropionaldehyde 1,2-Propandiol propionaldehyde propanediol dehydrase glycerol dehydrase ethanolamine deaminase Glutamate threo- -Methyl-L-aspartate glutamate mutase In each reaction the positions of the groups in boxes are exchanged. For the last three reactions, rearrangements of hydroxyl groups or an amino group leads to production of unstable intermediates. These are shown below. H 3 C H C H C H OH OH H 3 C C H H C O H H 2 C H C OH H C H OH OH H 2 C C OH H H C O H H 2 C H C H OH NH 3 + H 3 C C O H + NH 4 + + H 2 O + H 2 O propanediol dehydrase glycerol dehydrase ethanolamine deaminase

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