Lecture 34 — Translational Autism NEU335.pdf

Sally ann sally puts ball in basket then leaves room

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Sally & Ann Sally puts ball in basket, then leaves room. Ann puts the ball in the box instead. Sally comes back; where does she look for the ball?
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cation & “theory of mind” Amodio & Frith, 2006 mPFC in autism: gray matter (Deurden et al., Autism Res, 2011) mPFC connectivity in default mode network that correlates with social deficits (Assaf et al., Neuroimage, 2010) altered mPFC activity during social tasks (Dichter et al., Soc Cogn Affect Neurosci, 2009) Medial prefrontal cortex in social communication & “theory of mind”
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Autism models Inhibitory interneuron dysfunction in autism Altered Excitation-Inhibition (E-I) balance Intense world theory of autism Medial prefrontal cortex in social communication & “theory of mind” Autism as a “developmental disconnection syndrome”
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“Recent findings coupled with emerging anatomical and functional imaging studies suggest a potentially unifying model in which higher-order association areas of the brain that normally connect to the frontal lobe are partially disconnected during development.” Geschwind & Levitt, Curr Opin Neurobio , 2007 Autism as a “developmental disconnection syndrome”
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Autism as a “developmental disconnection syndrome” Corpus callosum: one of the 1 st brain areas found to be structurally abnormal in autism. Agenesis of the corpus callosum (AgCC): The ultimate disconnection syndrome! 1/2 have autism Kim Peek
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Autism models Inhibitory interneuron dysfunction in autism Altered Excitation-Inhibition (E-I) balance Intense world theory of autism Medial prefrontal cortex in social communication & “theory of mind” Autism as a “developmental disconnection syndrome”
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Autism Cells Circuits Behavior Genes
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Learning Objective Understand how the framework of “genes cells circuits behavior” relates to complex brain disorders like autism
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What is it? What causes it? What can we do about it? Autism Audrey C. Brumback, MD, PhD Dell Medical School 2018
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  • Spring '16
  • Colgin
  • Asperger syndrome, Han

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