Cancer progression and metastasis is typically associated with the most lethal

Cancer progression and metastasis is typically

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and distant sites. Cancer progression and metastasis is typically associated with the most lethal consequences of the disease-disruption of normal physiology. Metastatic disease responds poorly to most treatment approaches 5. What type of mutations might occur that cause proto-oncogenes to become oncogenes? a.   1. a mutation in the proto-oncogene that encodes for a protein w/ abnormal activity 2. overexpression of proto-oncogenes that aren't repressed when necessary 3. translocation which results in hybrid gene w/ abnormal function - gain-of-function mutation --> only 1 allele of proto-oncogene needs to be mutated to contribute to cancer --> oncogenes = DOMINANT cancer phenotype 6. How does p53 prevent cancer cells from forming? a. p53 also known as cellular tumor antigen p53 or phosphoprotein p53 or tumor suppressor p53 is a protein that in humans is encoded by the TP53 gene. The p53 protein is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor, preventing cancer. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation. Hence TP53 is classified as a tumor suppressor gene. © 2010 Project Lead The Way, Inc. Medical Interventions Activity 3.1.3 Student Response Sheet – Page 1
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  • Fall '10
  • Biology, Student Response Sheet, cancer cells, tumor antigen p53

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