A person who does not respond to one salicylate may respond to a different one

A person who does not respond to one salicylate may

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A person who does not respond to one salicylate may respond to a different one.
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Copyright © 2017 Wolters Kluwer • All Rights ReservedNSAIDsNSAIDsProvide strong anti-inflammatory and analgesic effectsSold over the counter, which may lead to abuseAnti-inflammatory, analgesic, and antipyretic effects
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Copyright © 2017 Wolters Kluwer • All Rights ReservedNonsteroidal Anti-inflammatory and Related Agents Nonsteroidal Anti-inflammatory and Related Agents Propionic Acids FenoprofenIbuprofenAcetic AcidsDeclofenacEtodolacFenamates Mefenamic acidCyclooxygenase-2 InhibitorsCelecoxib
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Copyright © 2017 Wolters Kluwer • All Rights Reserved
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Copyright © 2017 Wolters Kluwer • All Rights ReservedNSAIDSNSAIDSTherapeutic actions and indications - Block two enzymes, known as COX-1 and COX-2Pharmacokinetics- Rapidly absorbed from the GI tract, reaching peak levels in 1 to 3 hours. They are metabolized in the liver and excreted in the urineContraindications and cautions- Allergy to any NSAID or salicylate, and celecoxib is also contraindicated in the presence of allergy to sulfonamides, CV dysfunction or hypertension, peptic ulcer, GI bleeding, pregnancy, lactation, renal and hepatic dysfunction
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Copyright © 2017 Wolters Kluwer • All Rights ReservedNSAIDSNSAIDSAdverse effects- Nausea, dyspepsia, GI pain, constipation, diarrhea, or flatulence caused by direct GI effects of the drug. GI bleed, dizziness, somnolence, platelet inhibition, hypertension, and even bone marrow depressionDrug-to-Drug interactions- Decreased diuretic effect when these drugs are taken with loop diuretics; there is a potential for decreased antihypertensive effectof beta-blockers if these drugs are combined; and there have been reports of lithium toxicity, especially when combined with ibuprofen
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Copyright © 2017 Wolters Kluwer • All Rights ReservedNursing Considerations for Patients Receiving NSAIDs and Related AgentsNursing Considerations for Patients Receiving NSAIDs and Related AgentsAssess: Known allergies to any salicylates, NSAIDs, or tartrazineBaseline status before beginning therapy and for any potential adverse effectsPregnancy or lactation; hepatic or renal disease; CV dysfunction; hypertension; and GI bleeding or peptic ulcerPresence of any skin lesions; temperature; orientation, reflexes, and affect; pulse, blood pressure, and perfusion; respirations and adventitious sounds; liver evaluation; bowel sounds; and CBC, liver and renal function tests, urinalysis, stool guaiac, and serum electrolytes.
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Copyright © 2017 Wolters Kluwer • All Rights ReservedAcetaminophen Acetaminophen Actions- Acts directly on the thermoregulatory cells of the hypothalamusMechanism of action unknown but related to analgesic effectsUsed to treat pain and feverTreat pain and fever associated with a variety of conditions, including influenzaProphylaxis of children receiving diphtheria–pertussis–tetanus (DPT) immunizations Relief of musculoskeletal pain associated with arthritis
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