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16. Describe events of (step 5) remodeling. Include each of thefollowing:
a. medullary cavityformation – As cartilage breaks down in the interior, spaces form and merge intoa single central cavity. b. Capillaries and red bone marrow – The medullary cavity becomes filled with nutrients-carrying capillaries and red bone marrow connective tissue. c. Diaphysisformation – Bone matrix is secreted and creates the central bony shaft called the diaphysis. 17. Describe secondary ossification center formation. Include each of the following:a. When does this happen? This happens at the time of birth. Blood vessels entering the cartilaginous epiphysis initiate secondary ossification centers. b. Blood vessels entering the cartilaginous epiphysis? Blood vessels entering the cartilaginous epiphysis initiate secondary ossification centers. c. How does secondary ossification differ from primary ossification? Always occurs following the primary ossification process and does not result in the formation of a medullary cavity.d. Why does the interior of the epiphysis remain spongy? Due to the missing medullary cavity the inside of the epiphysis remain spongy. 18. Describe articular cartilage and epiphyseal plate formation. Include the following:a. Hyaline (articular) cartilage (location and function) – Due to the effect of secondary ossification, athin layer of hyaline cartilage is deposited on the surface of the epiphysis. This articular cartilage acts to reduce friction and shock within the articulating surfaces of the joint. b. Epiphyseal platelocation and function - The hyaline cartilagethat remains between the primary and secondary ossificationcenters forms the epiphyseal plate and allows the diaphysis tolengthen until puberty.Reference:Anatomy & Physiology (2012), OpenStax College, Rice University.