dramatically decreases a person’s chance of developing cardiovascular disease. Advising a patient on the importance of changing their lifestyle is a crucial factor in helping patients to avoid this calamitous disease process. Coronary Artery Disease Coronary blood flow brings oxygen to myocytes and removes waste products such as carbon dioxide, lactic acid, and hydrogen ions (Hammer & McPhee, 2014). Cellular ischemia occurs when there is either increased demand for oxygen relative to maximal arterial supply or an absolute reduction in oxygen supply (Hammer & McPhee, 2014). The particular mutations that have been most strongly linked as risk factors for venous thrombosis or for arterial thrombosis leading to coronary artery disease or stroke include those that affect fibrinogen, prothrombin (G20210A variant), factor V (factor V Leiden) of the coagulation system, PAI-1 of the fibrinolytic system, the platelet receptor GPIIIa, and methylenetetrahydrofolate reductase (MTHFR), as well as mutations that result in excessive levels of homocysteine (Huether & McCance, 2017). Through the build-up of the fatty deposits a patient develops CAD. Reduction of fatty foods through diet, exercise, life style changes, and lowering one’s cholesterol and weight are all ways to avoid this disease process, however genetics can play a role as well. The practitioner will need to educate the patient on various ways to avoid this and to make the necessary changes to their lives by referring patients to dieticians as well as cardiologists. References Hammer, G., McPhee, S. (2014). Pathophysiology of Disease: An Introduction to Clinical Medicine 7/E, 7th Edition . New York, NY. McGraw-Hill Learning Solutions.
Huether, S., & McCance, K. (2017). Understanding Pathophysiology, 6th Edition . St. Louis, MO. Mosby.
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