john_buscombe_tcm18-104082.pdf

Copyright american society of clinical oncology

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Copyright © American Society of Clinical Oncology Milowsky, M. I. et al. J Clin Oncol; 22:2522-2531 2004 Fig 2. Prostate-specific antigen (PSA) graphs for two patients at the 20 mCi/m2 dose level, demonstrating 70% (A) and 85% (B) declines in PSA lasting 8 and 8.6 months, respectively
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Copyright © American Society of Clinical Oncology Milowsky, M. I. et al. J Clin Oncol; 22:2522-2531 2004 Fig 3. Pretreatment (A,B) and 9-week posttreatment (C,D) computed tomography scans of the pelvis, revealing a partial response in lymphadenopathy seen in a patient with an 85% prostate-specific antigen decline treated at the 20 mCi/m2 dose level
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Three di-ScFv Forms Di-scFv format chosen for anti-cancer modules
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MAb Targeting Muc1 Aberrant Sugar or Peptide Core Protein in metastatic Ca Prostate
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RIT in brain tumours Pagenelli et al Milan leaders in this field Use antibodies directed against Tenascin, over expressed in gliomas Have used three step biotin-streptavadin approach On own and in combination with chemotherapy –Temozolomide 75% of patients treated showed stabilisation in rapidly growing tumours
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The three stage technique
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Conclusions New horizons depend on where you are looking from Advances unlikely to be cheap Best results will be based on molecular knowledge of disease Part of combination therapy likely to provide best answers to therapy of common tumours
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  • Fall '09
  • RIT, bone pain

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