2018 final exam key.pdf

Neu335 final name eid 18 hm lost his hippocampus

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NEU335 FINAL Name ________________________ EID ________ 18. HM lost his _hippocampus_ [brain region] in an e ff ort to cure his _epilepsy_ . Name three forms of memory or learning that were impaired after the surgery and three that were intact after the surgery (distinguish between “anterograde” and “retrograde” where appropriate). (8 pt) 19. Describe a synaptic capture (tagging) experiment. (8 pt) a. How is the experiment performed? two sets of inputs onto one cell that’s recorded; zap one side or both and measure LTP b. What is observed at each set of synapses? LTP at strongly-zapped inputs, but not weakly-zapped inputs, unless weak zap is close in time to strong zap c. What is the cellular mechanism? strong zap activates protein synthesis of factors that become available cell-wide; weak zap causes temporary local changes (CKII phosphorylation) that are able to take advantage of cell-wide factors, making the temporary changes more permanent Use this brain to answer questions 20-29. More than region may apply and a region may be used more than once. (10 pt) 20. Dentate gyrus ___A____ 21. CA3 ___B______ 22. CA1 ____C_____ 23. This area contains place cells ___C, B also okay_____ 24. Neocortex ___D_______ 25. Hypothalamus ___E______ 26. Adult neurogenesis ____A _____ 27. Sensory inputs project here ___D______ 28. Entorhinal cortex cells project here __A, C_______ 29. This brain is from a HUMAN/ MOUSE /APLYSIA/MACAQUE (1 pt) 119 total 5 Intact Impaired
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  • Spring '16
  • Colgin
  • synaptic inputs

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