Renin Angiotensin System Flashcards

Renin-angiotensin system
Terms Definitions
What does RAS stand for?
Renin Angiotensin System
What does RAAS stand for?
Renin Angiotensin Aldosterone System

(aka Renin Angiotensin System)
Low blood pressure stimulates kidney cells called ______ to produce ______.
juxtaglomerular

renin
Renin is a(n) ______.

enzyme/hormone
enzyme
Renin is secreted into the ______ by the ______.
blood

kidneys
Renin converts ______ into ______.
angiotensinogen
(AN-jee-oh-ten-SIN-o-jen)

angiotensin I
Angiotensinogen is a ______ produced by the ______.
plasma protein

liver
What does ACE stand for.
angiotensin converting enzyme
ACE is a(n) ______.

hormone/enzyme
enzyme
ACE converts ______ into ______ in the ______.
angiotensin I

angiotensin II

lungs
Where is ACE found?
the lungs
Angiotensin II is a(n) ______.

hormone/enzyme
hormone
Angiotensin II stimulates the ______ to produce ______.
adrenal cortex

aldosterone
Angiotensin II, besides stimulating aldosterone production, is also a powerful ______.
vasoconstrictor
Aldosterone increases sodium ______ in the kidneys, and ______ follows, increasing blood pressure.
reabsorbtion

water
Aldosterone is a ______corticoid.
mineral(corticoid)
Aldosterone increases reabsorbtion of ______.
Na+
Increased ______ in the extracellular fluid directly stimulates aldosterone secretion.
K+
The very first ACE inhibitor was called ______.
captopril
ACE inhibitors are primarily used in the treatment of ______ and ______.
hypertension

CHF
ACE inhibitors are often combined with ______ in the control of hypertension.
diuretics
The RAS in general aims to ______ blood pressure.
increase
ACE inhibitors ______ cardiac output and cardiac index.
increase
ACE inhibitors ______ arteriolar resistance and ______ venous capacitance.
lower

increase
ACE inhibitors lead to increased ______ (excretion of sodium in the urine).
natriuresis
With ACE inhibitor use, the effects of ______ are prevented, leading to decreased blood pressure.
angiotensin II
Follow the sequence from decreased systemic blood pressure (stimulus) to increased systemic blood pressure (effect).

(1) stimulus: decreased BP
(2) ______ cells secrete ______
(3) ______ converts ______ to ______
(4) ______ converts ______ to ______
(5)
Answers

(1) stimulus: decreased BP
(2) JUXTAGLOMERULAR cells secrete RENIN
(3) RENIN converts ANGIOTENSINOGEN to ANGIOTENSIN I
(4) ACE converts ANGIOTENSIN I to ANGIOTENSIN II
(5) ANGIOTENSIN II stimulates ALDOSTERONE secretion
(6) ANGIOTENSIN II also directly causes VASOCONSTRICTION
(7) effect: increased BP
Name 2 popular ACE inhibitors.
(1) Captopril
(2) Lisinopril
What is cardiac index?
A formula that relates cardiac output to body surface area, thus relating heart performance to the size of the individual.
What is cardiac index?
A formula that relates cardiac output to body surface area, thus relating heart performance to the size of the individual.
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