Different coagulation testing methodologies and Factor Information Flashcards

APTT
Terms Definitions
What laboratory evaluation of platelets does the following describe: Utilizes Platelet aggregometer, platelet rich plasma(37degC), and is stirred with a small magnetic bar to allow more light to pass through the suspension?
Aggregation Studies(principal in determing Primary Hemostasis)
Name the lab eval of platelets from the following hints: Congenital or Aquired D/O and assesses In-Vivo platelet function.
Bleeding Time
Can a periphial blood smear be used for aggregation studies of platelets?
Yes
What are the Factors involved in the Intrinsic Pathway Activation?
XII , XI , IX , VIII
What is the Factor involved in the Extrinsic Pathway Activation?
VII
What are the Factors involved in the Common Pathway Activation?
X , V , II , I
Name the Factors in the Fibrinogen group?
I, V , VIII , XIII
Name the Factors in the Prothrombin group?
II , VII , IX , X
Name the Factors in the Contact group?
XI, XII , HMWK , PK
What Factor group is Vitamin K dependent?
Prothrombin Group
Which Factor group is completely consumed in the coagulation process?
Fibrinogen Group
What Factor is consumed in the Prothrombin group during coagulation?
Factor II
What Factor group is not being synthesized during HDN?
Prothrombin Group
Limited Vit K storage and Vit K production is an indicator of what?
Immature liver
What is the treatment for HDN?
Vit K
During FDP test, latex particles in glycerine buffer are coated with __________ to human fibrinogen fragments: Frag ____ and Frag _____.
Specific Ab, D , E
Presence of FDP's in either serum or urine will cause latex particles to _______, yielding _____________ _____________.
clump, macroscopic agglutination
The latex particles provided in the D-Dimer Assay are coated with _______ anti-_______ D-dimer monoclonal bodies.
mouse, human
Test sample containing D-dimer when mixed with latex particle suspension make the particles __________.
agglutinate
Positive D-Dimer assay may be seen in clinical situations where active _________ is occuring such as DIC, DVT, and primary embolism.
thrombosis
Plasmin is formed in the absence of coagulation taking place describes what disorder?
Primary Fibrinolysis
Results from hypofibrinogenemic state induced by the proteolytic cleavage of fibrinogen by excess plasmin, in addition to the catabolic effect of the enzyme factors V and VIII.
Secondary Fibrinolysis
What are the three naturally occuring anti-coagulants?
Anti-thrombin III,Nat. Occuring Heparin, and Protein C & S (cofactor)
Name 3 aquired anti-coagulants?
Lupus Anticoagulant, Heparin, and Coumarin/warfarin
Coumarin/warfarin interferes with the recycling of what vitamin?
K
What test monitors coumarin/warfarin therapy?
PTT
Heparin acts to accelerate the rate of _________ by binding the serine protease, irreversibly inhibiting its activity.
anti-thrombin III
What test is used to monitor heparin therapy?
aPTT
Name the common laboratory screening tests for hemostatic D/O's?
PLT count, Periphial Smear, PTT, aPTT, TT, Bleeding Time.
What anticoagulant should be used in specimen collection?
sodium citrate
PT measures what factors?
I, II, V, X, VII (prothrombin group, due to the need of vitamin K)
PT helps to measure early Vitamin ___ deficiences.
K
Ref. Range for PT is ___ - ____ seconds.
10 - 13
aPTT evaluates the _______ pathway of coagulation.
intrinsic
The purpose of the aPTT is to screen for _________ in the intrinsic pathway.
inhibitors
The aPTT is clinically significant due to its ability to screen/detect circulating _________.
Anticoagulants
The ref. range for aPTT is ______ - ________ seconds.
25-35 seconds
Mixing studies are a diagnostic evaluation of unexplained prolonged ______ and ______ tests.
aPTT and PT
Mixing studies will only be performed when _________.
requested by a health care provider.
Mixing studies use commercially prepared ________ ___________ __________.
pooled normal plasma
What test evaluates the time required for thrombin to convert fibrinogen to an insoluble fibrin clot?
TT
The normal value time range should be ____ to _____ seconds.
10 - 15
what buffer is used when quantitatively measuring fibrinogen?
owren's veronal buffer (pH 7.35)
Normal value range for fibrinogen is _______ to ________ mg/dL.
200-400
What is the test used to screen for platelet dysfunction, testing mainly for primary hemostasis and platelet function.
BT
Name the 3 BT methods?
Ivy, Duke, and Mielke
what is the normal clotting time when performing the ivy testing method?
0-8 minutes.
Bernard Souliers Syndrome will show abnormal _______ and _________ during aggregation studies.
Thrombin and Ristocetin
Glanzmann's thrombasthenia is a deficiency in glycoprotein contents, all aggregation studies will show abnormal except for ________.
Ristocetin
Decreased production of prostacyclin is a key indicator of the secondary condition due to drugs or infx is ________________
Thrombotic Thrombocytopenic purpura
Acute blood loss, vigorous exercise, splenectomy, and hematopoiesis can all lead to _________ ___________.
reactive thrombosis
Adenocarcinoma, sepsis, and liver disease is most often accompanied by what secondary condition?
DIC
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