Alzheimer's treatments Flashcards

Terms Definitions
Cholinesterase inhibitors
MOA: maintain high levels of acetylcholine within the body by inhibiting the breakdown of acetylcholine. (Reversible. Selective for CNS). Thought to support nerve communication delaying progression. (6-12 months in 50% of patients)
Donepezil (Aricept)
Cholinesterase inhibitor
Galantamine (Razadyne)
Cholinesterase inhibitor
Rivastigmine (Exelon)
Cholinesterase inhibitor
Cholinesterase inhibitor *hepatotoxic*
NMDA antagonists
MOA: block NMDA receptor. Thought to block degeneration of neurons. Only partial blockage, allowing Ca2+/Na+ (myocardial function). Add-on therapy w/ACh inhibitor (3-6 month symptom stabilization)
Memantine (Namenda)
NMDA antagonist
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