Arrowsmith is a novel by American author and playwright Sinclair Lewis that was published in 1925. It won the 1926 Pulitzer Prize for Lewis but he refused to accept it. Lewis was greatly assisted in its preparation by science writer Dr. Paul de Kruif, who received 25% of the royalties on sales, but Lewis is listed as sole author. Arrowsmith is arguably the earliest major novel to deal with the culture of science. It was written in the period after the reforms of medical education flowing from the Flexner Report on Medical Education in the United States and Canada: A Report to the Carnegie Foundation for the Advancement of Teaching, 1910, which had called on medical schools in the United States to adhere to mainstream science in their teaching and research.