cell differentiation
process by which a cell becomes specialized to perform a certain function
cell memory
pattern of gene expression in daughter cells that gives them the same differentiation as the parent cell
combinatorial control
process by which eukaryotic cells regulate gene expression by organizing groups of transcription regulators to control expression of a single gene
DNA methylation
addition of methyl groups to cytosine nucleotides in the DNA strand
epigenetic inheritance
transmission of information from parent cell to daughter cell without mutations in the genome
functional RNA
noncoding RNA (ncRNA) that serves to regulate gene expression
microRNA (miRNA)
short ncRNA of about 17–25 nucleotides that binds to a specific mRNA and causes degradation or blocks translation of the mRNA
polyadenylation
addition of a chain of adenine (A) nucleotides to the 3′ end of the mRNA transcript
positive feedback loop
process in which the transcription factors required to activate transcription of the proteins the cell must produce are transcribed on the gene they activate
posttranscriptional control
modification to the mRNA applied after transcription
RNA interference (RNAi)
process of silencing RNA via the binding of complementary RNA
RNA-induced silencing complex (RISC)
complex of proteins that cleaves RNA
short interfering RNA (siRNA)
double-stranded RNA of about 20–25 nucleotides that protects the cell from infection
transcription
formation of RNA from the template DNA strand to be used to build proteins
translation
assembly of amino acids into proteins in the ribosomes through the reading of mRNA by tRNA and the ribosome