Signaling Pathways

Vocabulary

active state

open position of a ligand-gated ion channel, where ions are able to pass through across the membrane

adenylyl cyclase

effector protein that produces the second messenger cyclic AMP (cAMP) during cell signaling

cyclic AMP (cAMP)

second messenger molecule that regulates many different metabolic functions. It is found in nearly every organism.

dimer

union of two molecules, such as receptor tyrosine kinase molecules, which forms in response to receiving a signal

G-protein-coupled receptor (GPCR)

receptor that works in conjunction with G protein, which uses guanosine triphosphate (GTP) to activate an ion channel or an enzyme

ligand

molecule that binds to a specific receptor protein to initiate signal transduction

ligand-gated ion channel

receptor that acts as a gate, allowing ions into or out of the cell when a signaling molecule binds

receptor tyrosine kinase (RTK)

membrane receptor kinase that phosphorylates (adds a phosphate group to) the amino acid tyrosine of a substrate protein. Its action can lead to many different cellular responses.

second messenger

small molecule, such as cyclic AMP (cAMP), that carries a message from a membrane receptor into the cytoplasm or may not use the membrane receptor at all

voltage-gated ion channel

receptor that acts as a gate, allowing ions into or out of the cell in response to a change in electrical charge across the membrane