Brains, Biology, and Behavior

Genetics and Evolutionary Psychology

DNA, Genes, and Chromosomes

Genes, made up of DNA, are the basic units of heredity. Genes carry instructions for manufacturing proteins, which guide development and influence physical traits and behavior.
A gene is a unit of heritable material that codes for a particular trait. Genes carry instructions for manufacturing proteins that guide development. These instructions can influence an organism's behavior and psychological traits, just as they influence physical traits. Deoxyribonucleic acid (DNA) is an organic molecule containing coded instructions for the life processes of all living things. This genetic code is found inside the cells of every organism, providing the blueprint for the traits the organism expresses. When an organism grows, DNA replicates itself so each new cell created has an identical copy of the genetic information. This DNA, the genetic material that is passed from one generation to the next, is contained within a threadlike strand called a chromosome. Chromosomes are in the cell nucleus, which controls cell activity. Humans have 23 pairs of chromosomes. One set of chromosomes for each pair comes from a person's mother, and the other set comes from the father. Genes are sequences of DNA, and each chromosome contains many genes. A useful metaphor is that DNA constitutes a sequence of letters that spell out the genetic code. Genes are like meaningful words and sentences made of letters. Humans have about 20,000 genes, and each one influences development or day-to-day functions.

Location of Gene within DNA Strand

Genes are segments of DNA (the genetic code) contained within chromosomes. Chromosomes are located in the cell nucleus, which regulates cell activity.
The genetic code in an organism's cells is called the genotype. Humans and other living organisms carry two copies of each gene, although the copies may be different. A version of a gene is known as an allele. When one allele masks the expression of another, it is a dominant allele. The allele whose expression is masked is a recessive allele. When a gene has two identical alleles in the same location, it is homozygous. When a gene has two different alleles in the same location, it is heterozygous. An individual's phenotype involves all of the observable characteristics that result from genetic and environmental influences. For example, a person may have the genetic potential to grow very tall (genotype). However, if that person is malnourished in childhood, they may end up with below-average height (phenotype).

A heterozygous gene will express a phenotype related to the dominant allele. However, an organism with a heterozygous gene can pass the recessive allele to offspring. For example, the genotype of a brown-eyed individual may include two genes for the color brown. Alternatively, a brown-eyed individual may have one dominant gene for the color brown and one recessive gene for the color blue. If a brown-eyed person with the recessive gene for blue eyes has children with someone who also has a gene for blue eyes, their child can have blue eyes.

Heritability is the proportion of phenotypic variance attributable to genetic variance. For example, if individuals in a population differ in weight, these differences may be due to differences in their genetic makeup or their diet. The heritability of weight can be calculated as
Heritability=PhenotypicvariabilityduetodifferencesingenesPhenotypicvariabilityduetodifferencesingenesandenvironment\mathrm{Heritability}=\frac{\mathrm{Phenotypic}\;\mathrm{variability}\;\mathrm{due}\;\mathrm{to}\;\mathrm{differences}\;\mathrm{in}\;\mathrm{genes}}{\mathrm{Phenotypic}\;\mathrm{variability}\;\mathrm{due}\;\mathrm{to}\;\mathrm{differences}\;\mathrm{in}\;\mathrm{genes}\;\mathrm{and}\;\mathrm{environment}}
To calculate heritability, there must be genetic variability. If a gene occurs in every member of a population and is passed on to every offspring in that population, then the heritability of that gene is zero. Some traits are more heritable than others, in part because they are less strongly shaped by environmental influences. For example, heritability of height is about 0.90, of personality about 0.50, and of religious beliefs about 0.30–0.40. Most traits are shaped by multiple genes. There is no one gene that determines height or personality.

Evolution

Genes that code for beneficial traits are likely to be passed on to future generations because they help an organism survive and reproduce.
Evolution is the change in relative frequency of genes in a population over time. There are four mechanisms of evolutionary change: mutation, genetic drift, gene flow, and natural selection. Mutation refers to errors that occur during DNA replication that can result in new heritable traits. In genetic drift, changes in gene frequency occur due to chance. For example in 1775 a typhoon reduced the population of the Micronesian island of Pingelap to only 20. One of the survivors had a genetic variation that causes complete color blindness. The prevalence of color blindness in Pingelap is now 5%. In most populations, it is less than 1%. Gene flow refers to organisms migrating to new geographic locations, thereby changing the frequency distribution in the old and new locations.

Natural selection is a mechanism of evolution in which individuals that are better adapted to their environment survive and reproduce more successfully than less well adapted individuals do. Natural selection was proposed by English naturalist Charles Darwin in his book On the Origin of Species, published in 1859. Variation exists in the traits of members of most species, some of which is heritable. If these heritable traits confer survival advantages, individuals with these traits will be healthier or survive longer. This allows them to produce more offspring than members of their species with less successful traits. Individual reproductive success is referred to as fitness, defined as the number of copies of one's genes passed to subsequent generations. This is the type of fitness referred to in the common phrase survival of the fittest. The phrase does not mean that the physically strongest survive. Instead it means that those best suited to their environment survive. The outcome of natural selection is adaptation to specific environments. An adaptation is a process or trait that improves an organism's ability to survive or reproduce in a given environment.

Structural adaptations are the heritable physical features of an organism. An example is sickle cell anemia, an inherited blood disorder in which the body makes an abnormal form of hemoglobin (a protein that transports oxygen in blood). The disease is caused by inheriting two defective copies of a particular gene. The gene has spread because inheriting only one defective copy offers protection against the mosquito-borne disease malaria. The highest proportion of the gene variant is found among people from regions where malaria is prevalent, such as West Africa, Southeast Asia, the Middle East, and China.

Behavioral adaptations are the things organisms do to survive in their physical and social environments. These adaptations can be inherited, learned, or a combination of both. For example, birds migrating south in the winter to find food is an inherited behavioral adaptation. The tendency of humans and other animals to cooperate with others is an adaptation that is inherited but also learned.

Epigenetics

Genes and the environment interact to shape physical and psychological traits. Genetic factors can influence environmental responses, and environmental factors can alter gene expression.
Heredity and the environment work together to shape physical and psychological traits. Genetic factors can influence environmental responses. In turn, the environment can shape genetic activity.

Psychologists use twin and adoption studies to understand genetic and environmental influences. In these studies, identical and fraternal twins raised in the same family are compared to twins who were separated at a young age and raised in separate families. These studies show that genes contribute to many physical and psychological traits, including intelligence, personality, careers, hobbies, weight, political beliefs, religious beliefs, and mental health. Twin studies also reveal the importance of the environment. Identical twins have very similar gene expression early in life. As they age, twins raised in different environments develop more epigenetic differences. Twins raised separately differ more in psychological traits and health histories than those raised together.

Genetic factors influence risk for mental illness. For instance, depression occurs when levels of a neurotransmitter called serotonin drop too low. Variation exists in a serotonin transporter gene (5-HTTLPR) that influences risk of depression following stressful life events. People with a short variant of the gene are more vulnerable to depression than those with a long variant. Individuals with the short variant experience increased activity in the amygdala (part of the brain involved with emotions such as fear and aggression) following a stressful event and are more likely to dwell on negative experiences. Researchers estimate that genes account for 50% of depression risk, environmental events account for 10%, and intentional activities (e.g., rumination) account for 40%.

Environmental factors can also lead to changes in the expression of the genetic code. Epigenetics is the study of these heritable changes in the expression of genes that are caused by the environment. Many genes require specific environmental circumstances to be expressed and may therefore never be expressed.

Gene expression is regulated through the process of methylation. Each gene has a "tail" called a histone. The addition of a methyl (CH3) molecule to this tail deactivates the gene. Removing the tag allows the gene to become active. Environmental factors such as diet and stress levels can influence gene methylation. Epigenetic change can be passed down across generations because children can inherit methyl tags from parents.

For example, all mammals have a gene called agouti. Mice with methylated agouti genes are slim, healthy, and covered in brown fur. Mice with unmethylated agouti genes are obese, prone to diabetes and cancer, and covered in yellow fur. Pregnant yellow mice who are fed a methyl-rich diet give birth to pups with brown fur who remain healthy for life.

Epigenetic Change in Gene Expression

Genes can be turned off by adding a small molecule called a methyl group to DNA. Genes can be turned on by adding a different molecule, called an acetyl group, to a part of the DNA strand called the histone tail. These changes to genes can endure over time and even be passed on to offspring.
Epigenetics can affect psychological traits as well. Children who grow up in poverty have more methylation in an area of the brain that responds to fear stimuli (the amygdala) than children not raised in poverty. Chronic stress also leads to decreases in the size of telomeres, a protective cap at the end of chromosomes. Shorter telomeres predict more rapid aging and age-related health problems.