aminoglycoside
antimicrobial that disrupts bacterial protein synthesis and is used to treat aerobic gram-negative infections
antibiotic
antimicrobial chemotherapy agent used as a drug for the treatment of a bacterial infection
antibiotic stewardship
coordinated program that helps improve the usage of antibiotics in increasing human health while decreasing resistance and costs of using them
antimetabolite
chemical that impedes the use of the appropriate metabolite in a biochemical pathway
bacitracin
antibiotic that blocks the formation of cell walls
bactericidal
resulting in the death of bacterial cells
bacteriostatic
causing microbial replication to fail inhibiting the growth of bacteria
beta-lactamase
enzyme that hydrolyzes the beta-lactam ring, effectively providing multidrug resistance against entire groups of beta-lactam antibiotics
broad-spectrum antibiotics
antibiotics that are effective against many different types of microbes
cephalosporin
beta-lactam antibiotic with some resistance to beta-lactamase that is effective against gram-positive and some gram-negative bacteria
chromosomal resistance
antimicrobial resistance conferred by genes coded on the bacterial chromosome
disk diffusion method
method that allows for testing large numbers of antimicrobial chemicals against a microbial strain
ETEST
test that allows for the determination of the lowest concentration of an antimicrobial necessary to stop microbial growth
extrachromosomal resistance
antimicrobial resistance conferred by genes not coded on the bacterial chromosome, typically on plasmids
imidazole
azole antifungal group widely used in agriculture and for the topical treatment of skin infections such as athlete's foot
minimum bactericidal concentration (MBC)
lowest concentration of an antimicrobial necessary to kill 99.9% of bacterial cells
minimum inhibitory concentration (MIC)
lowest concentration of an antimicrobial necessary to stop microbial growth
narrow-spectrum antibiotics
antibiotics that are effective against smaller, more specific groups of microbes, such as gram-negative or gram-positive bacteria but not both
penicillin
group of broad-spectrum antibiotics that inhibit bacterial cell wall synthesis
penicillinase
enzyme that catalyzes the hydrolysis of the beta-lactam ring of a penicillin drug
persister cell
bacterial cell susceptible to an antibiotic that survives through a course of the antibiotic
polymyxin
antimicrobial with detergent-like properties that disrupts the membranes of gram-negative bacteria
quinolone
any of a large group of broad-spectrum antibiotics sharing a common chemical form that target bacterial DNA gyrase and are used in human and veterinary medicine for the treatment of bacterial infections
rifamycin
antimicrobial that alters the activity of enzymes in the liver, causing them to metabolize other drugs into metabolites with more potent liver toxicity
selective toxicity
ability to kill a microbe or inhibit microbial growth while exhibiting minimal toxicity to the patient
serum killing power
lowest concentration of a patient's serum that effectively inhibits a pathogen's growth
superinfection
secondary infection occurring following antibiotic treatment when a second pathogen is resistant to the original antibiotics
tetracycline
antimicrobial that inhibits bacterial protein synthesis and is prescribed for a wide range of infections
therapeutic dose
minimum quantity of a drug necessary to treat a patient