## Alpha Carbon Reactions

A conjugate addition (or 1,4-addition) is a reaction in which a nucleophile reacts with an alpha,beta-unsaturated carbonyl compound in the beta position. For conjugate addition, alpha,beta-unsaturated carbonyls can be prepared using a halogenation reaction on the alpha carbon of the carbonyl, followed by the addition of a weak base (commonly pyridine) to form a double bond. Nucleophiles that are strong bases (for example, Grignard and organolithiums) attack the carbonyl group by 1,2 addition (simple addition) in an irreversible reaction. Nucleophiles that are weaker bases tend to react at the beta carbon of the ${\rm{C{=}C}}$ through 1,4 addition (conjugate addition) in a rapid, though reversible, reaction.
The Michael reaction (or Michael addition) is a 1,4-addition reaction in which a carbanion is added to an alpha,beta-unsaturated carbonyl compound. The Michael reaction involves the nucleophilic addition of a carbanion to an alpha,beta-unsaturated carbonyl, and it is used to form ${\rm{C{-}C}}$ bonds.