Laboratory B and C: Four Coordinate Nickel Complexes
In depth understanding:
Tolman, Chem. Rev., 19
Laboratory D: Nickel-Catalyzed SuzukiMiyaura CrossCoupling in a Green Alcohol Solvent
Seechurn, C. J.; Kitching, M. O.; Colacot, T. J.; Snieckus, V. "Palladium-Catalyzed
Cross-Coupling: A Historical Contextual Perspective to the 2010 N
Laboratory F: Measurements of Excited State Electron Transfer
by Fluorescence Quenching of Ruthenium(II) Tris Bipyridine
Experimental Physical Chemistry, Ed. G.P. Matthews; Clarendon Press, Oxford 1985, pg
For deeper study:
Schlenk Line Technique
Different researchers use Schlenk lines to exclude different levels of oxygen and moisture
depending on the sensitivity of their compounds. Just as drying tubes alone were sufficient for
the Grignard, sparging with nitrogen is suffi
Understanding Lab E: The SN1CB Mechanism
The mechanism by which the cobalt reaction occurs is called the SN1CB mechanism.
Given the uniqueness of rapid ligand loss from Co(III), it is no surprise that the base hydrolysis
mechanism has been extensively stu
Laboratory A: Octahedral Nickel complexes and the
Kilner, M.;Smith, J. M. d8 energy level diagram: An experiment for advanced students J.
Chem. Educ., 1968, 45, 94-97.
Duncan, Jeremy. Experiment 6: Using a Nickel Spect
to gain technical competence in
experimental methods in inorganic
synthesis including air sensitive methods
to work with modern spectroscopic methods
for the characterization of inorganic
For the next two weeks
groups will run Cobalt kinetics on the RedTide UV-Vis spectrometers (will take most of
Three groups will sign up for staggered times
on fluorimeter to measure e
November 30th and December 2nd
I will provide a list of sample
Your first questions will be from the
sample questions. You will then get a
few follow up questions to clarify your
9/21-9/23: Finish synthesis and
characterization of nickel complexes.
Some students need to do NMR at the
9/28-9/30 Suzuki coupling and
Try not to keep sample
Set up Suzuki coupling (there is lots to
Finish characterization/magnetism. Make
sure that you have all the data you need
for the report this week. Attach spectra to
I am happy to help either in person or by email. You can email for an
appointment or you can drop by and see if I am available.
. . . . That part of the formal scientific method called experimentation
There is no post lab due next week
Check in at the end of the period to let us
know how far you have gotten
Remember to leave your areas clean (you
can leave at the glassware we give you for
You were not responsible for the
assignment of 3, 4 and 5.
Solvent will coordinate to a 14
The complex is not activated by
reductive elimination of Cl2
Cl- bonding would change the
1926 Pernicious anemia could be
effectively treated by feeding
patients large amounts of liver
1946 Active ingredient was a Co
Crystal structure: Hodgkin
Lab E: Kinetics of a ligand substitution reaction of a cobalt(III)
Intro Chem textbook on kinetics and mechanism
Roecker, Lee. Synthesis and Base Hydrolysis of a Cobalt(III) Complex Coordinated
by a Thio
Lab H: Synthesis of Ferrocene
Werner, H. "At Least 60Years of Ferrocene: The Discovery and Rediscovery of the
Sandwich Complexes" Angew. Chem. Int. Ed. 2012, 51, 6052-6058.
Ferrocene is an organometallic complex a molecule with direct
Lab D: Standardization of Sodium Hydroxide
What is a primary standard?
How do we perform a titration with an indicator?
Watch the video on standardization (panopto)
Watch the video on the titration (you tube, technique)
Do the prelab qu
Come to the NMR room at the designated time. Will rotate NMR/ Spectroscopy/
Glove Box/ Schlenk Line
1. What is the purpose of shimming? How can you tell that the machine is poorly shimmed?
2. What is the purpose of locking to a solvent signa