Solid Phase Organic Chemistry: Amide Synthesis
CHEM352L, Summer 2012
In solid phase organic synthesis (SPOC), a reactant or reagent is "immobilized" on a solid
support, such as polymeric beads made of polystyrene or silica gel. "Immobilized" simply means
(1) Draw the structure of cis-norbornene-5-6-endo-dicarboxylic anhydride and mark
chiral carbons (if any). Is this molecule chiral or achiral?
(2) Why do we use excess cyclopentadiene in the reaction? (There may be m
Experiment 37: Aldol Condensation
1. Assuming that the yield or synthesis of dibenzalacetone is 60%, calculate how much
benzaldehyde and acetone you need to use to obtain 5.30 g of the final product.
2. Describe briefly how would you de
TEA, CH2Cl2, RT