Chapter 10 Thought Questions
1. Why is the acquisition of an immortalized proliferative potential so important for human
2. What types of evidence connect telomeres and telomerase to entrance into the senescent
state, and what alter
Thought Questions Chapter 3
1) What observations favor or argue against the notion that cancer is an infectious disease?
Favor: In 1876, a Russian researcher found that the transmission of a tumor from on dog
to another was caused by removi
Thought Questions Ch. 4
1) What evidence do we have that suggests that endogenous retrovirus genomes play little if
any role in the development of human cancers?
The majority of ERVs that occur in vertebrate genomes are ancient, inactivated
1. Why is pRb function compromised in human tumors through mutations of its
encoding gene while the genes encoding its two cousins, p107 and p130, have
virtually never been found to suffer mutations in the genomes of cancer cells?
Chapter 5 Thought Questions
1) Why is autocrine signaling an intrinsically destabilizing force for a normal tissue?
The autocrine signaling destabilizing forces for normal cell, because normal cells
do not synthesize and release a growth fa
Chapter 6 Thought Questions
1) What molecular mechanisms have evolved to ensure that the signals coursing down a signaling cascade
reach the proper endpoint targets rather than being broadcast non-specifically to unintended targets in
Exam 3 Study Guide
1. Why is pRb function compromised in human tumors through mutations of its encoding gene while the
genes encoding its two cousins, p107 and p130, have virtually never been found to suffer mutations in
the genomes of cancer ce
Cancer Bio Study Guide 2
1. Why is autocrine signaling an intrinsically destabilizing force for a normal tissue?
a. Autocrine signaling is an intrinsically destabilizing force for a normal tissue because it is an
auto-stimulatory signaling loop.
Chapter 12 - Thought Questions
1. What types of evidence suggest that karyotypic alterations of cell genomes are not
absolutely essential for neoplastic transformation?
a. Karyotypic normally describe large alterations of cell genomes
Chapter 7 Thought Questions
1) Why is the inheritance of mutant, activated oncogenes responsible for only a small
proportion of familial cancer syndromes, while the inheritance of defective tumor
suppressor genes (TSGs) is responsible for t
Chapter 13 - Thought Questions
1. What diverse lines of evidence prove directly that most carcinoma cells depend on stromal
cell types for various types for various types of physiologic support?
a. Figure 13.1 is titled the stromal componen
1. In light of the fact that DNA tumor viruses must suppress the apoptosis of infected cells in
order to multiply, what molecular strategies are available for them to do so?
What are some ways to shut down apoptosis? Last bullet point above the
Chapter 11 - Thought Questions
1. Knowing the various genetic and epigenetic changes that occur during multi-step
tumorigenesis, which of these would you say are likely to be readily uncovered and which
may be difficult to be identify? Desc
Chapter 2: The Nature of Cancer
1. The cells that form a tumor are the result of an error in the normal development of cells and
tissue. Pathologists use histology, which is the examination of thin layers of cancerous tissue,