We can characterize the antagonists compounds by different agonists conc.
Pka and Pkb are characteristics of competitive antagonists.
- The more shifting of Ec50 to the right, the more antagonists conc ;.
- Lock and key model was not sufficient
- Two state receptors model can determine the ligand if it is agonist, neutral antagonist,
and inverse antagonist.
Theyre some endogenous molecules that reduce the efficacy, so they washed
Daniel M. Negusse, Summer 2011
Use the notes at your own risk
May 16, 2011
PSW 380 Toxicology
Introduction & Dose Response
Steven D. Cohen, D.Sc., ATS
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