Systemic Lupus Erythematosus (SLE)
SLE affects almost exclusively young women. It is characterized by its periodicity (flares).
Frequently begins with non-specific flu-like inflammation, fatigue, and weight loss. This process
is most often started by infe
RA is an autoimmune disease with chronic, symmetric erosion of the peripheral joints that is
additive, not migratory.
It occurs twice as frequently in women as in men.
Clinical Presentation of RA
Often there is morning stiffness, swel
NSAIDS inhibit COX, the enzyme responsible for synthesis of prostaglandins.
Be able to explain specificity of COX1 vs. COX2 functions, differentiate the reversible from
irreversible COX inhibitors, and describe the importance of aspirins mixed-orde
Gout affects 1% of men. Prevalence is increasing due to obesity and diuretic use.
Acute gout attacks are an inflammatory arthritis with redness and swelling in the joint. Often
confused with bacterial cellulitis. Usually it is in one joint, often the
Vasculitis is characterized by inflammatory destruction of blood vessels resulting in occlusion or
destruction of the vessel, and ischemia of tissues supplied by that vessel. There is no
single pathognomonic feature.
General signs include subac
There are three pathways of complement activation: classical, lectin, and alternative pathways.
Classical pathway is activated by antibodies acting on C1.
Lectin pathway substitutes mannose-binding lectin (MBL) in place of C1. MBL, like C
LECTURE OUTLINES STUDY GUIDE
Kinetics: abrupt onset usually resolves in 3-7 days; if chronic, attacks become more frequent and last longer
- Initial: monoarticular usually big toe (podagra), resembles cellulitis
- Chronic: swelling and
Pharmacology of Gout
Uric acid is created by xanthine oxidase. Purines (adenosine, guanine) are metabolized
to xanthine, which is then converted by xanthine oxidase into uric acid.
Catabolism of purines to uric acide is important for nitrogen excretion th
Scleroderma (Systemic Sclerosis)
Scleroderma is characterized by tissue fibrosis caused by a specific autoimmune mechanism.
The most common signs include hardened skin, followed by lung, GI, vascular, and heart.
It occurs 3-7 more frequently in women, mos
Intro to Rheumatic Diseases
Rheumatic diseases are inflammatory diseases of connective tissue.
The pace development of a disease gives clues to its driving force
Acute diseases: gout. Initiating force is exogenous and recognizable (in the case of gout, it