Notes: The Age
Age of Materials
Human civilizations are often divided into ages according to the materials
that dominate in the society. For example, in the Stone Age, when the tools were
largely made of stones, people used those si
Lecture 5 Notes: NMR
Background of speaker: Used NMR as a tool to study complex protein dynamics. Currently
utilizes little NMR; studies molecular biology/protein engineering to build genes from
scratch for protein synthesis.
NMR can be look at biomolecul
Lecture 6 Notes: Practical Aspects of Single Crystal X-ray Crystallography, Part
X-ray diffraction was key to solving structures such as RNA and collagen. However, X-ray
crystallography of fibers is extremely difficult, because the fibers entangle rathe
Lecture 2 Notes: Chemical and physical properties of amino acids
Ribosomes are assembly lines found in humans, plants, algae and bacteria alike.
Polymerases are natural copy machines. They do not make mistakes often. They make 1
mistake per billion copyin
Lecture 3 Notes: Beta Sheets
Administrative announcements: Take-home exam at the end of next week.
Introduction to Beta-sheets:
Beta sheets can appear in a variety of arrangements. Last time, we saw that alpha-helices can
organize into a higher-order stru
Lecture 4 Notes: Practical Aspects of Single Crystal X-ray Crystallography, Part
Next Tuesday: Guest lecturer on NMR.
Next Thursday: Guest lecturer on other characterizations
methods. Following Tuesday: Institute holiday!
Lecture 10 Notes: Biomineralization:
Bones and Teeth
Bones and teeth can be mineralized and fossilized. The insoluble calcium and bones and
teeth is held together with proteins, the crystal structure of which is not entirely known.
Read The Material
Lecture 9 Notes: Biomineralization and
Hands-on demo: observation of seashells.
Consider the many biological process evident from an abalone shell. The outside is covered
with barnacles: next time, well look at the chemistry of how
Lecture 8 Notes: Silk and its
Take-home midterm is out! You have almost 1 month to turn it in.
On question 10, you are asked to design a creative, novel material. In the past,
students have designed ingenious materials. Gradua
Lecture 7 Notes: Analytical Approaches and Instrumentation
Four nucleotide bases can combine in millions of combinations to make DNA molecules.
These are interpreted to make proteins with primary, secondary, tertiary, and quaternary