Action Potentials Lecture Handout
I suggest you write notes in the blank spaces and margins
How action potentials work
Epilepsy and anticonvulsants
Local anesthetics (e.g. Novocaine)
Alcohol and alcohol antagonists
What is an alcohol antagonist? An alcohol antagonist is a drug that specifically blocks the
effects of alcohol. If you take an alcohol antagonist and then drink a bunch of alcohol, it should
theoretically prevent you from getting drunk
Zaks Definition of Addiction:
Addiction is continued use of a substance despite harms that outweigh the benefits, with a
lack of control over substance use.
A person may also be addicted to a behavior instead of a substance, such as gambling addiction.1
Your name: _
Recreational Drugs and Neurotransmitters Quiz
I. Name at least one example from each drug class:
3. A different kind of sedative
5. A different kind of stimulant
8. A diff
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Dose-Response Curves and Intrinsic Efficacy
Many real-life dose-response curves are complex or poorly understood. However, some are well
understood and follow simple models.
The Michaelis-Menten model is quite simple and very accurate in some
A dose-response curve is a graph with dose on the x-axis and response on the y-axis.
Things to plot on the x-axis:
Size of oral dose, in mg
Size of IV dose, in mg
Size of oral dose per body weight, in mg/kg
Size of dose per body surfa
Appetite and Nausea Chart
How to read this chart:
Neurotransmitters are in bold.
Drugs are inside a little black box.
Different neurotransmitters are separated by a thicker black line.
This is roughly organized as a spectrum - things on the far left make
Disclaimer: Do not misuse drugs. Do not use drugs for fun. Take drugs exactly as prescribed by a trustworthy doctor, and do not fear
necessary prescription drugs because of terrible side effects on this chart (which, by the way, may be inapplicable or ext
The Steps of Neural Signaling
The steps below represent the path taken by the information being communicated, the message,
the signal itself.
Step 1: Afferent (incoming) action potential arrives
Location: Presynaptic terminal
Inhibited by: Et
Drug Addiction, Dopamine, and Liking vs.
Food Reward: Brain Substrates of Wanting and Liking by Kent C. Berridge; Neuroscience and
Behavioral Reviews, Vol. 20, No. 1, pp. 1-25, 1996.
Dopamine in drug abuse and addiction: results fro
Lecture 5 Pharmacokinetics Companion
Pharmacokinetics vs. Pharmacodynamics:
Pharmacodynamics is what drugs do to your body what receptors the drugs bind to,
whether they are agonists or antagonists
Pharmacokinetics is what your body does to drugs: