What cells primarily produce 5-HT or serotonin?
Where is the highest concentration of serotonin producing neurons found in
Dorsal Raphe Nucleus and rostral Raphe nucleus
What is serotonin synthesized from?
What enzyme conve
Miller-Fisher syndrome is a type of GuillianBarre Syndrome however,
what is different?
Paralysis of eye muscles, ophthalmoplegia
Charcot-Marie-Tooth is a _ disorder?
If the PMP 22 portion of chromosome 17 isrepeated (duplicated) wha
1. What is the rate-limiting enzyme for dopamine production from
a. Tyrosine Hydroxylase
What is Dopamine directly synthesized from (justafter tyrosine)?
What enzyme converts L-dopa to Dopamine?
1. Where is
What are the agonist and antagonist fornicotinic receptors?
Nicotine- agonist, curarae antagonist
What are Muscarine and Atropine?
Muscarinic receptor agonist (muscarine) andantagonist (atropine)
What two ways can glutamate get synthe
1. What enzyme facilitates the transformation of norepinephrine into
PNMT or phenylethanolamine N-methyltransferase
1. What is the only adrenergic receptor that does not stimulate a
a. Alpha 2
1. What do alpha 2 receptors also fu
What enzyme facilitates the transformation of glutamate into GABA?
Glutamic Acid Decarboxylase
GABA is known as the Chief what?
Besides GABA what other neurotransmitter also is chiefly inhibitory?
What kinds of channels
What neurotransmitter can inhibit the opening of Ca+ channels or increase
the efflux of K+ to inhibit the presynaptic neuron?
What does amphetamines do?
increase the release of dopamine
What does Fenfluramine do?
stimulates the release of serotonin
What are the 4 demyelinating diseases we looked at in class?
Guillian- Barre Syndrome
Which demyelinating disorder works from the CNS to PNS?
What ages are commonly affec
Ptosis of eyelids is what?
lazy, droopy eyes
neostigmine and pysostigmine do what?
what does nerve gas cause?
How does nerve gas affect you?
irreversibly inhibits acetylcholinesterase
What does Curare do?
ACh, Glu, GABA, Serotonin
How many proteins and how many times dometabotropic receptors
span the membrane?
One protein spans the membrane 7 times
What do metabotropic receptors interact with?
What are the three portions of
Talk to me about the Flexor (withdrawl) reflex?
its a polysynaptic reflex that remains ipsilateral on the side that the
Talk about the crossed extensor reflex?
Its a polysynaptic, contralateral reflex where both inhibitory and excitat
What transport protein is defective in ALD?
PEX or PTS1R
1. What world renowned scientist was famous for coining the term
What are Dales 5 rules to being a neurotransmitter?
Must be synthesized in the nerve term
Acetylcholine is the combination of what 2 substrates?
Choline and Acetyl coenzyme A
1. What enzyme facilitates the combination of choline and Acetyl
a. Choline Acetyltransferase
What are the 2 broad types of receptors for