Welcome
Biology of Aging
Lecture 1
What will the course be like
Mechanisms and theories of aging
Medical aspects
Cutting edge research
Conflicting theories, controversies
The course is based on research
articles, no textbook
TAs
Mehr Kashyap
Sara Bener
Biology of Aging
Lecture 8
Is there a trade-off between longevity and
reproduction in humans?
Le Bourg E. Does reproduction decrease longevity in human beings? Ageing Res Rev.
2007 Aug;6(2):141-9.
Comparisons within populations. Important to consider soci
Biology of Aging
Lecture 10
Cancer and Aging
Overexpression of telomerase
2-fold increase in the rate of wound healing
2-fold increase in tumor formation
Mouse telomeres are already too long, this
result indicates that telomerase has additional
role in
Biology of Aging
Lecture 9
Telomeres and telomerase
continued
2009 Nobel prize in Medicine
Correlation between telomere length
and social status
Divided the SES into nonmanual (white-collar)
workers (I-IIIN) and manual (blue-collar) workers
(IIIM-V)!
Mean
Biology of Aging
Lecture 12
Aging in p53 mutant mice
Oncogene activation
(Inappropriate instructions)
DNA damage
Hypoxia
Heat or cold shock
Viral infections
Nutrient depletion
p53
Growth arrest
DNA repair
Senescence
Apoptosis
These effects are induced ver
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